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PROPHYLACTIC AND THERAPEUTIC AGENT FOR NEUROLOGICAL DISEASES USING LIPOPROTEINS AND PROPHYLACTIC AND THERAPEUTIC METHOD FOR NEUROLOGICAL DISEASES

Foreign code F130007292
File No. S2011-1105-N0
Posted date Apr 11, 2013
Country WIPO
International application number 2012JP073920
International publication number WO 2013/042684
Date of international filing Sep 19, 2012
Date of international publication Mar 28, 2013
Priority data
  • P2011-205390 (Sep 20, 2011) JP
  • P2012-119680 (May 25, 2012) JP
Title PROPHYLACTIC AND THERAPEUTIC AGENT FOR NEUROLOGICAL DISEASES USING LIPOPROTEINS AND PROPHYLACTIC AND THERAPEUTIC METHOD FOR NEUROLOGICAL DISEASES
Abstract

The purpose of the present invention is to provide a prophylactic and therapeutic agent for neurological diseases, said agent comprising as an active ingredient apolipoprotein E-containing lipoproteins or having as an action mechanism a neuroprotective system through the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors, and a prophylactic and therapeutic method for neurological diseases. The aforesaid apolipoprotein E-containing lipoproteins and/or neuroprotective system through, as the action mechanism, the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors have prophylactic and therapeutic effects of, for example, inhibiting nerve cell apoptosis, on neurological diseases such as various neurodegenerative diseases accompanied by nerve cell apoptosis as the essential condition. Therefore, the present invention provides a prophylactic and therapeutic agent for neurological diseases, said agent comprising apolipoprotein E-containing lipoproteins and/or having an action mechanism through the activation of neuroprotective molecules and the inactivation of neurodegeneration-inducing molecules that are mediated by lipoprotein receptors, and a prophylactic and therapeutic method for neurological diseases. The prophylactic and therapeutic agent for neurological diseases and the prophylactic and therapeutic method for neurological diseases according to the present invention are useful for preventing and treating neurological diseases such as Alzheimer's disease, glaucoma and diabetic retinopathy.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY,
  • NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY
  • Inventor
  • HAYASHI HIDEKI
IPC(International Patent Classification)
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