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METHOD FOR INDUCING HEPATOCELLULAR VARIATION, AND PRODUCTION METHOD FOR CHIMERIC NON-HUMAN ANIMAL HAVING HUMANIZED LIVER

Foreign code F130007302
File No. S2011-1043-N0
Posted date Apr 17, 2013
Country WIPO
International application number 2012JP075019
International publication number WO 2013/047720
Date of international filing Sep 28, 2012
Date of international publication Apr 4, 2013
Priority data
  • P2011-215977 (Sep 30, 2011) JP
Title METHOD FOR INDUCING HEPATOCELLULAR VARIATION, AND PRODUCTION METHOD FOR CHIMERIC NON-HUMAN ANIMAL HAVING HUMANIZED LIVER
Abstract

The present invention provides (1) a production method for a non-human animal having a humanized liver, said method comprising transplanting human liver stem cells and/or liver precursor cells and/or immature liver cells to a non-human animal having liver damage, and inducing liver cell variation, (2) a non-human animal having a humanized liver produced using said method, (3) a method using said animal to investigate the pharmacokinetics and/or hepatotoxicity of a substance to be tested, (4) a production method for human liver cells, said method comprising transplanting human liver stem cells and/or liver precursor cells and/or immature liver cells to a non-human animal having liver damage, and inducing liver cell variation, and (5) a method using the human liver cells produced using said method to investigate the pharmacokinetics and/or hepatotoxicity of a substance to be tested.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
  • Inventor
  • TANIGUCHI, HIDEKI,
  • ZHENG, YUN-WEN
IPC(International Patent Classification)
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