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METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL

Foreign code F130007309
File No. S2012-0020-N0
Posted date Apr 24, 2013
Country WIPO
International application number 2012JP076048
International publication number WO 2013/051722
Date of international filing Oct 5, 2012
Date of international publication Apr 11, 2013
Priority data
  • P2011-222138 (Oct 6, 2011) JP
  • P2012-076080 (Mar 29, 2012) JP
Title METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL
Abstract

The purpose of the present invention is to provide: a method for producing a corneal endothelial cell, particularly from a neural crest stem cell originated from a parenchyma of cornea or an iPS cell, with high efficiency

a method for producing a corneal endothelial cell in a large quantity in a steady manner by inducing the differentiation of a stem cell into the corneal endothelial cell more efficiently

and a medicinal agent comprising a corneal endothelial cell. A method for inducing the differentiation of a corneal endothelial cell from a stem cell, comprising a step of culturing the stem cell in a differentiation-inducing culture medium containing a GSK3 inhibitor (preferably a GSK3beta inhibitor) and retinoic acid, preferably additionally containing at least one component selected from the group consisting of TGFb2, insulin and a ROCK inhibitor

and others.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KEIO UNIVERSITY
  • Inventor
  • SHIMMURA, SHIGETO,
  • HATOU, SHIN,
  • TSUBOTA, KAZUO,
  • YOSHIDA, SATORU
IPC(International Patent Classification)
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