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COMBINATION MEDICINE FOR TREATMENT OF DEPRESSION

Foreign code F130007313
File No. S2012-1213-N0
Posted date Apr 26, 2013
Country WIPO
International application number 2012JP001996
International publication number WO 2012/127871
Date of international filing Mar 22, 2012
Date of international publication Sep 27, 2012
Priority data
  • 201161466157P (Mar 22, 2011) US
Title COMBINATION MEDICINE FOR TREATMENT OF DEPRESSION
Abstract

The present invention provides a combination medicine for treatment of depression, comprising a combination of (A1) an antidepressant and either (B1) a dopamine D1 receptor agonist or (C1) a dopamine D1 receptor antagonist

and a method for screening for an antidepressant that in combination with a dopamine D1 receptor agonist provides an improvement in treatment of depression, the method comprising the steps of: administering, to a mammal, (A2) a compound having an antidepressant action and (B1)a dopamine D1 receptor agonist, and detecting a greater increase in depression-related gene expression, dopamine D1 receptor expression and/or dopamine D1 receptor signaling in comparison with the case where (A2) the compound having an antidepressant action or (B1) the dopamine D1 receptor agonist is administered.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KURUME UNIVERSITY,
  • NIPPON MEDICAL SCHOOL FOUNDATION,
  • SCHOOL JURIDICAL PERSON FUJITA EDUCATIONAL INSTITUTION,
  • THE ROCKEFELLER UNIVERSITY,
  • NISHI, AKINORI,
  • KOBAYASHI, KATSUNORI,
  • MIYAKAWA, TSUYOSHI,
  • GREENGARD, PAUL
  • Inventor
  • NISHI, AKINORI,
  • KOBAYASHI, KATSUNORI,
  • MIYAKAWA, TSUYOSHI,
  • GREENGARD, PAUL
IPC(International Patent Classification)
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