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ANTIBODY REACTING WITH NATIVE COCHLIN-TOMOPROTEIN (CTP) AND METHOD FOR MEASURING CTP USING SAME

外国特許コード F130007314
整理番号 S2012-1237-N0
掲載日 2013年4月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP058988
国際公開番号 WO 2012133898
国際出願日 平成24年4月2日(2012.4.2)
国際公開日 平成24年10月4日(2012.10.4)
優先権データ
  • 特願2011-080052 (2011.3.31) JP
発明の名称 (英語) ANTIBODY REACTING WITH NATIVE COCHLIN-TOMOPROTEIN (CTP) AND METHOD FOR MEASURING CTP USING SAME
発明の概要(英語) Immunological measurement is carried out using an anti-CTP antibody, characterized by recognizing an epitope contained in a polypeptide represented by amino acid numbers 118 to 132 in SEQ ID NO: 1 and reacting with native Cochlin-tomoprotein (CTP).
従来技術、競合技術の概要(英語) BACKGROUND ART
Or less Cochlin-tomoprotein(, referred to as CTP) is, present in the perilymph of the isoform 16kDa is the molecular weight of Cochlin, cerebrospinal fluid, blood, saliva and the like can be present in the middle ear not found other fluids include, the perilymph fistula has been expected as a diagnostic marker (patent document 1, non-patent document 1-5). Is a perilymph fistula, and the inner ear is spaced from the window opening a hole in the inner ear, middle ear perilymph satisfying the inner ear to leak out of the inner ear dysfunction in exhibit disease. Of the inner ear to early closing the window in order to improve the symptoms, diagnosis at an early stage is very important.
The present inventor's research group, so far, in order to measure the CTP in the biological sample, a synthetic peptide as an immunogen one rabbit polyclonal antibody 4 (Patent Document 1) was prepared. However, that all antibodies reacted only with modified CTP, antibodies reactive with native CTP has not yet been obtained. Therefore, in non-patent document 1-5, the resulting modified CTP-recognizing anti-LCCL3 antibody (not respond to the native CTP) using, in a biological sample by a western blot CTP is being measured.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SAITAMA MEDICAL UNIVERSITY
  • 発明者(英語)
  • IKEZONO, Tetsuo
  • SHIKAZE, Satomi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

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