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SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE

Foreign code F130007333
File No. S2011-0633-C0
Posted date Apr 26, 2013
Country WIPO
International application number 2012JP059021
International publication number WO 2012/141038
Date of international filing Apr 2, 2012
Date of international publication Oct 18, 2012
Priority data
  • P2011-091599 (Apr 15, 2011) JP
Title SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE
Abstract

The purpose is to select a low-molecular-weight compound which is effective for inducing the differentiation of a mesenchymal stem cell into a hepatocyte and develop a differentiation-inducing method which has excellent efficiency of inducing a mesenchymal stem cell into a hepatocyte and is safe. At least one compound selected from compounds represented by formula (1) and formula (2), a salt of the compound, or a solvate of the compound or the salt

a differentiation-inducing agent comprising at least one compound selected from compounds represented by formula (1) and formula (2), a salt of the compound, or a solvate of the compound or the salt

and a differentiation-inducing agent comprising a compound represented by formula (8), a salt of the compound or a solvate of the compound or the salt.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY,
  • TOKYO WOMEN'S MEDICAL UNIVERSITY,
  • SHIOTA, GOSHI,
  • HOSHIKAWA, YOSHIKO,
  • MATSUMOTO, NORIKO,
  • MATSUMI, YOSHIRO,
  • MORIMOTO, MINORU,
  • TONOI, TAKAYUKI,
  • SAIMOTO, HIROYUKI,
  • OHASHI, KAZUO,
  • OKANO, TERUO
  • Inventor
  • SHIOTA, GOSHI,
  • HOSHIKAWA, YOSHIKO,
  • MATSUMOTO, NORIKO,
  • MATSUMI, YOSHIRO,
  • MORIMOTO, MINORU,
  • TONOI, TAKAYUKI,
  • SAIMOTO, HIROYUKI,
  • OHASHI, KAZUO,
  • OKANO, TERUO
IPC(International Patent Classification)
Reference ( R and D project ) (In Japanese) ヒト間葉系幹細胞を肝細胞へ分化誘導する新規化合物の合成と解析
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