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LOW-MOLECULAR-WEIGHT COMPOUND CAPABLE OF REGULATING RAC ACTIVATION INDUCED BY DOCK-A SUBFAMILY MOLECULE, AND USE THEREOF

Foreign code F130007352
File No. S2013-0032-N0
Posted date May 14, 2013
Country WIPO
International application number 2012JP060390
International publication number WO 2012/157389
Date of international filing Apr 17, 2012
Date of international publication Nov 22, 2012
Priority data
  • P2011-109334 (May 16, 2011) JP
Title LOW-MOLECULAR-WEIGHT COMPOUND CAPABLE OF REGULATING RAC ACTIVATION INDUCED BY DOCK-A SUBFAMILY MOLECULE, AND USE THEREOF
Abstract

Provided is a novel medical use application for a pyrazolidinedione derivative represented by formula (1) and having an activity of inhibiting the activation of Rac through DOCK2, DOCK180 or DOCK5. Specifically provided is a medical use application for the derivative as a prophylactic or therapeutic agent for Rac activity-related diseases such as various immune-related diseases including autoimmune diseases and malignant tumors or an immunosuppressing agent. [In formula (1), Z represents a methine group (C-H) or a nitrogen atom (N)

X represents a substituent represented by formula (2)

R1 and R2 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a hydroxy group, or an alkyl group having 1-4 carbon atoms

and n represents an integer of 0-2.]

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION,
  • THE UNIVERSITY OF TOKYO,
  • FUKUI, YOSHINORI,
  • NISHIKIMI, AKIHIKO,
  • KANAI, MOTOMU,
  • KOHDA, DAISUKE,
  • SAITOH, TAKASHI
  • Inventor
  • FUKUI, YOSHINORI,
  • NISHIKIMI, AKIHIKO,
  • KANAI, MOTOMU,
  • KOHDA, DAISUKE,
  • SAITOH, TAKASHI
IPC(International Patent Classification)
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