TOP > 外国特許検索 > PROPHYLACTIC OR THERAPEUTIC AGENT FOR VIRUS INFECTIOUS DISEASE

PROPHYLACTIC OR THERAPEUTIC AGENT FOR VIRUS INFECTIOUS DISEASE UPDATE

外国特許コード F130007370
整理番号 S2012-0056-N0
掲載日 2013年5月22日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP078053
国際公開番号 WO 2013065690
国際出願日 平成24年10月30日(2012.10.30)
国際公開日 平成25年5月10日(2013.5.10)
優先権データ
  • 特願2011-239383 (2011.10.31) JP
発明の名称 (英語) PROPHYLACTIC OR THERAPEUTIC AGENT FOR VIRUS INFECTIOUS DISEASE UPDATE
発明の概要(英語) The present invention provides a prophylactic or therapeutic agent for a virus infectious disease, in particular a prophylactic or therapeutic agent for an enveloped virus infectious disease, said agent comprising a γ-interferon-inducible lysosomal thiol reductase expression vector or a γ-interferon-inducible lysosomal thiol reductase mimic.
従来技術、競合技術の概要(英語) BACKGROUND ART
In the treatment of viral infection, by repeating the viral mutations, drug resistance is a big problem occurs. Human immunodeficiency virus (HIV) caused by an infection acquired immune deficiency syndrome (AIDS) will be, many agents that prevent the growth of virus in combination, the therapeutic effect of the constant HAART - - multidrug combination therapy has been mentioned. However, still a problem and the emergence of resistant virus, infection by a new mechanism of action HIV inhibitor and the development of therapeutic agents has been desired.
The viral film has a lipid bilayer, the surface of the virus envelope protein (Env) having, referred to as enveloped viruses. Enveloped virus may be, the other HIV, murine leukemia virus similar directional heterologous virus (XMRV), vesicular stomatitis virus (VSV) and an influenza virus and the like are known.
Is enveloped virus, the infection in the target cell surface receptor after binding, taken into the endosome by endocytosis. Of the reduced pH within endosomes, the shift to the lysosome, viral envelope protein is, the low pH lysosomal specific proteolytic or activated by the action of an enzyme. Envelope protein is activated, causing fusion of the viral membrane, penetrating into the virus infects the cells. Envelope protein is, by disulfide bonds, essential for infection of target cells to maintain a higher-order structure is known.
Cleavage of the disulfide bond of the envelope protein compound (5, 5 - dithiobis (2 - nitrobenzoic acid) (DTNB) ) is, it is possible to suppress HIV infection (non-patent document 1) are known. Is DTNB, protein disulfide isomerase present on the surface of the host cell such as by inhibiting (PDI), of the cellular HIV are believed to inhibit tumor cell invasion. However, many proteins of the host due to its disulfide bonds, wherein said compound, acts on many proteins derived from a host, cell toxicity is a problem. Non-patent document 1 is also, enzymes such as PDI chioredakudaze or when used, the effect of inhibiting the infection of virus infected or is promoted is described.
On the other hand, the interferon treatment of the host cell, by inducing various anti-viral agents, viral infections are known to suppress. Expression is induced by interferon γ innate immunity factors as one of the 1, γ interferon induction lysosomal thiol reductase (gamma interferon inducible lysosomal thiolreductase(GILT) ) is known. Is GILT, break the disulfide linkage of the antigen, by protease digestion for clarity, MHC-presented antigen is essential for the production of peptides have been reported (non-patent document 2). However, the functions of such GILT, provide a direct influence on the viral infection is not known whether or not.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NAGASAKI UNIVERSITY
  • 発明者(英語)
  • KUBO, Yoshinao
  • KAMIYAMA, Haruka
  • KAKOKI, Katsura
  • HAYASHI, Hideki
  • MATSUYAMA, Toshifumi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
上記の特許・技術に関心のある方は、下記問い合わせ先にご相談下さい。

PAGE TOP

close
close
close
close
close
close