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METHOD FOR DETECTING CHRONIC SINUSITIS

外国特許コード F130007371
整理番号 S2012-0038-N0
掲載日 2013年5月22日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP078008
国際公開番号 WO 2013065671
国際出願日 平成24年10月30日(2012.10.30)
国際公開日 平成25年5月10日(2013.5.10)
優先権データ
  • 特願2011-238913 (2011.10.31) JP
発明の名称 (英語) METHOD FOR DETECTING CHRONIC SINUSITIS
発明の概要(英語) The present invention provides a method for detecting chronic sinusitis, comprising measuring the concentration of periostin protein in blood or a nasal cavity secretion solution collected from a subject. Thus, a method for detecting chronic sinusitis can be provided, which can be achieved in a simpler, rapid and less-invasive manner.
従来技術、競合技術の概要(英語) BACKGROUND ART
Chronic sinusitis is, due to inflammation of the sinus cavity, a natural orifice are swollen mucosa with a closed, mucus or nasal cavity of the paranasal sinus polyps tissue (nasal polyps) stored in the papermaking machine is generated, rhinorrhea, nasal congestion, post-nasal drip, zuomo the clinical symptoms of a disease causing feeling and the like. May vary and is the cause of chronic sinusitis, bacterial or viral infection, allergic reaction, genetic predisposition, and the like of the living environment is considered. In addition, as the method for the treatment of chronic sinusitis, administration of antibiotics and, various types of surgical procedures is performed.
In addition, various kinds of allergic rhinitis is caused by an allergic reaction, and similar symptoms of chronic sinusitis, chronic sinusitis is by the appearance and physical findings difficult to discriminate. On the other hand, the treatment of allergic rhinitis, the administration of an anti-allergic agent can be effective, both diseases can be easily distinguished from an appropriate action that is desired to be performed.
However, as a method for the diagnosis of chronic sinusitis, generally up to now and the endoscopic examination of a tissue within the nasal cavity is used and the roentgen examination, a doctor in the diagnostic method of the inspection and evaluation is required, but not necessarily simple, has been a great burden to the patient as well.
In addition, in recent years, nasal polyps or surgical specimens the site of inflammation of the tissue by microscopic observation and diagnosis of chronic sinusitis has been performed. This is because, at the site of inflammation in chronic sinusitis, eosinophils and neutrophils infiltration around the cytokines, growth factors, adhesion factors and proinflammatory substances such as inflammation-related material can be used to enhance the present invention, the presence or absence of these substances by the concentration of the diagnosis of chronic sinusitis is carried out. For example, to Patent Document 1, a hematopoietic-type prostaglandin D synthase at the site of inflammation (H-PDGS) protein expression, or prostaglandin D2 (PDG2) measured by a texture observation amount, and the severity of chronic sinusitis disclosed are methods for diagnosing. The present inventors, the surgical specimens studied the expression of the protein and fibroblast , chronic sinusitis and allergic rhinitis at sites from the increase in the expression of fibroblast and chronic sinusitis and allergic rhinitis diagnosis to distinguish are reported (Non-Patent Document 1).
However, such as in surgical specimens of such a diagnostic marker for inflammation-associated material, enforcement facility are limited, it takes time to obtain a result, the nasal cavity to the patient during the acquisition of the tissue or the like to be associated with complications such as invasion is associated with. Therefore, further by a simple method, a medical specialist to improve the accuracy of the diagnosis, the non-specialist chronic sinusitis and in order to accurately diagnose the development of new tools have been sought.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SAGA UNIVERSITY
  • YAMAGATA UNIVERSITY
  • 発明者(英語)
  • IZUHARA Kenji
  • OHTA Shoichiro
  • ARIMA Kazuhiko
  • SHIRAISHI Hiroshi
  • SUZUKI Shoichi
  • OHTA Nobuo
  • ISHIDA Akihiro
  • SUZUKI Yusuke
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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