IMPDH INHIBITOR HAVING MICRORNA AS ACTIVE COMPONENT
Provided is a novel IMPDH inhibitor based on miRNA. This IMPDH inhibitor has, as an active component, oligonucleotides based more specifically on a miR-19a. The oligonucleotides based on miR-19a comprise a base sequence shown in any of 1) to 5) below: 1) the base sequence represented by sequence number 1 (UGUGCAAAUCUAUGCAAAACUGA)
2) the base sequence represented by sequence number 2 (AGUUUUGCAUAGUUGCACUACA)
a base sequence obtained by substitution, deletion, insertion, or addition of one to three nucleotides to a base sequence shown in sequences 1 or 2
base sequences complementary to the base sequences of oligonucleotides shown in any of 1) to 3) above
and base sequences which encode any of the oligonucleotides in 1) to 4) above. The aforementioned oligonucleotides suppress biosynthesis of IMPDH proteins by acting on the mRNA of the IMPDH gene, and can function as an IMPDH inhibitor.