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CYTOKINE-CHEMOKINE MODULATOR

Foreign code	F130007451
Posted date	Jul 4, 2013
Country	WIPO
International application number	2012JP062230
International publication number	WO 2012/153854
Date of international filing	May 11, 2012
Date of international publication	Nov 15, 2012
Priority data	P2011-107707 (May 12, 2011) JP
Title	CYTOKINE-CHEMOKINE MODULATOR
Abstract	The invention provides novel means for modulating the expression of cytokine-chemokine genes associated with inflammation and infection. Specifically, the invention provides an antisense nucleotide that comprises the sequence complementary to the 3'UTR of the CCL2, CCL20, CX3CL1, IL-23A, CD69, NF-?B p65, TNF-a, Fam89a, Grk5, phosopholipid scramblase 1, Runx1, semaphorin 4A, Steap4, lymphotoxin ss Psmb10 or TLR2 gene induced by IL-1ss and that is capable of modulating the expression of the gene sense oligonucleotide that contains the sequence complementary to the endogenous antisense transcription product containing the sequence complementary to the 3'UTR of the gene and that is capable of modulating the expression of the gene and an agent that prevents and/or treats inflammatory disease or infection and contains the sense or antisense nucleotide.
Applicant ※All designated countries except for US in the data before July 2012	THE RITSUMEIKAN TRUST, NISHIZAWA, MIKIO, OKUMURA, TADAYOSHI
Inventor	NISHIZAWA, MIKIO, OKUMURA, TADAYOSHI
IPC(International Patent Classification)	C12N 15/09 Recombinant DNA-technology A61K 31/7088 Compounds having three or more nucleosides or nucleotides A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics C12N 15/113 Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides C12Q 1/68 involving nucleic acids G01N 33/15 Medicinal preparations G01N 33/50 Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing G01N 33/68 involving proteins, peptides or amino acids

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Contact Information for " CYTOKINE-CHEMOKINE MODULATOR "

Ritsumeikan University Office of Sciences and Engineering Research
URL: http://www.ritsumei.ac.jp/eng/html/research/
E-mail:
Address: 1-1-1, Nojihigashi, Kusatsu, Shiga, Japan , 525-8577
Phone: 81-77-561-2802
Fax: 81-77-561-2811

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Contact Information for " CYTOKINE-CHEMOKINE MODULATOR "

Ritsumeikan University Office of Sciences and Engineering Research
URL: http://www.ritsumei.ac.jp/eng/html/research/
E-mail:
Address: 1-1-1, Nojihigashi, Kusatsu, Shiga, Japan , 525-8577
Phone: 81-77-561-2802
Fax: 81-77-561-2811

Related data

Gazette	WO 2012/153854(PDF,2862KB)