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CYTOKINE-CHEMOKINE MODULATOR

Foreign code F130007451
Posted date Jul 4, 2013
Country WIPO
International application number 2012JP062230
International publication number WO 2012/153854
Date of international filing May 11, 2012
Date of international publication Nov 15, 2012
Priority data
  • P2011-107707 (May 12, 2011) JP
Title CYTOKINE-CHEMOKINE MODULATOR
Abstract

The invention provides novel means for modulating the expression of cytokine-chemokine genes associated with inflammation and infection. Specifically, the invention provides an antisense nucleotide that comprises the sequence complementary to the 3'UTR of the CCL2, CCL20, CX3CL1, IL-23A, CD69, NF-?B p65, TNF-a, Fam89a, Grk5, phosopholipid scramblase 1, Runx1, semaphorin 4A, Steap4, lymphotoxin ss Psmb10 or TLR2 gene induced by IL-1ss and that is capable of modulating the expression of the gene

sense oligonucleotide that contains the sequence complementary to the endogenous antisense transcription product containing the sequence complementary to the 3'UTR of the gene and that is capable of modulating the expression of the gene

and an agent that prevents and/or treats inflammatory disease or infection and contains the sense or antisense nucleotide.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • THE RITSUMEIKAN TRUST,
  • NISHIZAWA, MIKIO,
  • OKUMURA, TADAYOSHI
  • Inventor
  • NISHIZAWA, MIKIO,
  • OKUMURA, TADAYOSHI
IPC(International Patent Classification)
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