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PROTEASOME INHIBITOR

Foreign code F130007461
Posted date Jul 4, 2013
Country WIPO
International application number 2012JP065992
International publication number WO 2012/176878
Date of international filing Jun 22, 2012
Date of international publication Dec 27, 2012
Priority data
  • P2011-139235 (Jun 23, 2011) JP
Title PROTEASOME INHIBITOR
Abstract

[Problem] To provide a novel proteasome inhibitor which can be administered orally. [Solution] A proteasome inhibitor comprising, as an active ingredient, a compound represented by general formula (1) [wherein Y and Y' are the same as or different from each other and independently represent a single bond, -O-, -NH-, -CH=CH?, -CO-CH=CH?, -O-CONH?, -S-CO?, -CONH?, -NHCO? or NHSO2? [wherein "?" represents a bond located on the phenyl group side]

R1, R2, R3, R4, R5, R6, R7 and R8 are the same as or different from one another and independently represent a hydrogen atom, a halogen atom, a hydroxy group, an amino group, a carboxyl group, a C1-6 alkyl group, a C1-6 alkoxy group or a C1-6 alkoxycarbonyl group

R9 and R10 are the same as or different from each other and independently represent a hydrogen atom or a C1-6 alkyl group, or R9 and R10 together form -CH2CH2- or -CH2CH(R11)CH2- [wherein R11 represents a hydrogen atom, a C1-6 alkoxy group or a C1-6 alkylsulfonyloxy group]

and m and n are the same as or different from each other and independently represent an integer of 2-4] or a salt thereof, or a solvate of the compound or the salt.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • EDUCATIONAL FOUNDATION JICHI MEDICAL UNIVERSITY,
  • KOWA COMPANY, LTD,
  • FURUKAWA, YUSUKE,
  • KIKUCHI, JIRO
  • Inventor
  • FURUKAWA, YUSUKE,
  • KIKUCHI, JIRO
IPC(International Patent Classification)
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