MEDICINAL AGENT FOR EVADING IMMUNE RESPONSE
|Posted date||Jul 9, 2013|
|International application number||2012JP069800|
|International publication number||WO 2013024710|
|Date of international filing||Aug 3, 2012|
|Date of international publication||Feb 21, 2013|
|Title||MEDICINAL AGENT FOR EVADING IMMUNE RESPONSE|
|Abstract||It is found that the immunostimulatory activity of nano particles on myeloid dendritic cells can be decreased and the phagocytosis of the nano particles by macrophages can also be decreased when the surfaces of the nano particles are modified with a RolA protein. The present invention provides nano particles each modified with a biological molecule having an immune-response-evading function.|
|Outline of related art and contending technology||
Metal element as an element containing ultra-fine particles of nanometer size (for example, metal oxide nanoparticles and the metal hydroxide nanoparticles) is, the catalyst, storage material, luminescent material, fluorescent material, material for a secondary battery, the electronic component material, a magnetic recording material, polishing material, optoelectronic, pharmaceutical, such as cosmetics in various fields are expected to be used. And the material to use particles of nanometer size, its extremely small size associated with interesting properties resulting in many cases be known. Such materials include engineering, electronic, mechanical, and chemical properties of the in some embodiments, the existing different properties of the bulk material have been reported. Particularly a magnetic nanoparticles and an increasing attention, is occurring or studied. Magnetic nanoparticles including the metal-element-containing nanoparticles may be noted in the properties of an attractive nature, quantum nature, a close relationship with the magneto-optical properties and, in a wide range of applications of the industrial and scientific attention. The magnetic nanoparticles comprise a, the magnetic fluid or a high density recording material, many materials such as medical diagnosis are expected to be applied.
The magnetic nanoparticles comprise a, they have desirable application from researchers in various fields have been developed recently gained increasing attention due to the (non-patent document 1 from 4). Magnetite (magnetite, Fe3 O4) is, chemically non-toxic to humans from esters such as, for example, use as a drug or gene delivery carriers, for use in the treatment of the cancer (hyperthermia therapy), in biosensor applications, including medical implant of reproduction (tissue engineering) including application in tissue engineering, Fe3 O4 suggested its use for many medical and, has been studied (non-patent document 5 from 8).
In order to achieve this is for medical applications such as, Fe3 O4 and sufficiently small, water or blood without good agglomeration as are required. In addition, captured by the phagocytic cells including macrophages so as not to, that is, with respect to the immunological reaction in the human body to have stealth properties is demanded. Fe3 O4 nanoparticles, various methods have been synthesized (non-patent document 9), and the properties of their surfaces, a number of approaches including the ligand exchange method can be changed (non-patent document 10 from 15).
Without being trapped by phagocytic cells, the half-life in the blood for prolonging the life (non-patent document 16), with various polymers such as polyethylene glycol to make the iron oxide nanoparticles have been attempted to coat (non-patent document 17 from 20). However, in these methods, the individual method can be applied in addition to practically difficult, during displacement between the solvent of the problem arose that the stability of the dispersion (non-patent document 21).
In addition, the nanoparticles are greater than 200 nm, can be trapped by phagocytic cells of the spleen have been reported (non-patent document 22).
In addition, the group of inventors of the present invention, metal hydroxide or metal oxide nanoparticles in a nanoparticle as a method, such as the sub-critical water or supercritical water in the water-temperature and high-pressure hydrothermal synthesis field is to develop a technique (patent document 1 from 5).
|Scope of claims||
(In Japanese)請求の範囲 [請求項1]
|IPC(International Patent Classification)||
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
Contact Information for " MEDICINAL AGENT FOR EVADING IMMUNE RESPONSE "
- Tohoku University Intellectual Property Division
- URL: http://www.rpip.tohoku.ac.jp/en/
- Address: 6-6-10 Aramaki Aza Aoba, Aoba-ku Sendai, Miyagi, JAPAN , 980-8579
- Fax: 81-22-795-5286