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USE OF MYELIN BASIC PROTEIN AS A NOVEL GENETIC FACTOR FOR RHEUMATOID ARTHRITIS

Foreign code F130007484
File No. 2701
Posted date Jul 10, 2013
Country WIPO
International application number 2012JP060426
International publication number WO 2012/144512
Date of international filing Apr 18, 2012
Date of international publication Oct 26, 2012
Priority data
  • P2011-095625 (Apr 22, 2011) JP
Title USE OF MYELIN BASIC PROTEIN AS A NOVEL GENETIC FACTOR FOR RHEUMATOID ARTHRITIS
Abstract

A novel genetic factor for rheumatoid arthritis is searched and used as a diagnostic marker. An examination method for rheumatoid arthritis which involves detecting an autoantibody against myelin basic protein in a biological sample from a subject. A rheumatoid arthritis examination kit containing myelin basic protein. A rheumatoid arthritis diagnostic marker containing antibodies against myelin basic protein. A method for determining the risk of rheumatoid arthritis morbidity, said method involving identifying the single nucleotide polymorphism of the base on the myelin basic protein gene of the subject or the single nucleotide polymorphism of a base having linkage disequilibrium with the base on the myelin basic protein gene of the subject. A kit for determining the risk of rheumatoid arthritis morbidity, said kit containing a nucleic acid probe and/or a nucleic acid primer capable of detecting the single nucleotide polymorphism of the base on the myelin basic protein gene of the subject or the single nucleotide polymorphism of a base having a linkage disequilibrium with the base on the myelin basic protein gene of the subject. A method for screening substances which are effective for the prevention of rheumatoid arthritis and/or effective as a therapeutic agent against rheumatoid arthritis, said method involving measuring the expression amount of the myelin basic protein gene or the gene product thereof after adding a substance to be evaluated into the cell expressing the myelin basic protein gene.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO UNIVERSITY,
  • MATSUDA, FUMIHIKO,
  • MIMORI, TSUNEYO,
  • OHMURA, KOICHIRO,
  • TERAO, CHIKASHI
  • Inventor
  • MATSUDA, FUMIHIKO,
  • MIMORI, TSUNEYO,
  • OHMURA, KOICHIRO,
  • TERAO, CHIKASHI
IPC(International Patent Classification)
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