Top > Search of International Patents > Therapeutic drug for adult T-cell leukemia

Therapeutic drug for adult T-cell leukemia

Foreign code F130007505
Posted date Jul 10, 2013
Country United States of America
Application number 200913120114
Gazette No. 20110172185
Gazette No. 8765719
Date of filing Aug 20, 2009
Gazette Date Jul 14, 2011
Gazette Date Jul 1, 2014
International application number JP2009064557
International publication number WO2010032582
Date of international filing Aug 20, 2009
Date of international publication Mar 25, 2010
Priority data
  • P2008-242867 (Sep 22, 2008) JP
  • P2008-256620 (Oct 1, 2008) JP
  • P2009-068750 (Mar 19, 2009) JP
  • 2009WO-JP64557 (Aug 20, 2009) WO
Title Therapeutic drug for adult T-cell leukemia
Abstract (US8765719)
An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect.
The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a prodrug thereof, wherein R1 is H, OH, an alkoxy group, an acyl group, or a thioacyl group, R2 is an acyl group, a thioacyl group, CONR7R8, or CSNR7R8 (R7 and R8 being each independently H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group), or R1 and R2 together may form a ring, X1 and X2 may be the same or different and are each ―CR3R4―, ―SiR3R4― or oxygen, and R3 and R4 may be the same or different and are each an alkyl group containing 1 to 6 carbon atoms.
Scope of claims [claim1]
1. A method for treating adult T-cell leukemia comprising administering to a subject in need thereof a therapeutically effective amount of a compound represented by the formula I:
wherein
R1 is H, OH, an alkoxy group, a linear or branched, saturated or unsaturated aliphatic acyl group containing 1 to 10 carbon atoms, a benzoyl group, a naphthoyl group, a linear or branched, saturated or unsaturated aliphatic thioacyl group containing 1 to 10 carbon atoms, a thiobenzoyl group, or a thionaphthoyl group, and
R2 is a linear or branched, saturated or unsaturated aliphatic acyl group containing 1 to 10 carbon atoms, a benzoyl group, a naphthoyl group, a linear or branched, saturated or unsaturated aliphatic thioacyl group containing 1 to 10 carbon atoms, a thiobenzoyl group, a thionaphthoyl group, CONR7R8, or CSNR7R8, wherein R7 and R8 are each independently selected from H, an alkyl group containing 1 to 3 carbon atoms, or a phenyl group, or
R1 and R2 together form a ring as represented by -- OCH2CH2CO -- or -- OCH.dbd.CHCO -- ,
X1 and X2 are each independently selected from -- CR3R4 -- and -- SiR3R4 -- , and
R3 and R4 are each independently selected from an alkyl group containing 1 to 6 carbon atoms; wherein the compound represented by the formula I is a compound represented by the following formula:
[claim2]
2. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula III:
[claim3]
3. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula IV:
[claim4]
4. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula VI:
[claim5]
5. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula A:
[claim6]
6. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula B:
[claim7]
7. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula E:
[claim8]
8. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula F:
[claim9]
9. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula G:
[claim10]
10. The method of claim 1, wherein the compound represented by the formula I is a compound represented by formula M:
  • Inventor, and Inventor/Applicant
  • BABA MASANORI
  • HASHIMOTO YUICHI
  • KAGOSHIMA UNIVERSITY
IPC(International Patent Classification)
Please contact us by E-mail if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close