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SKIN INTRODUCTION SYSTEM AND LIGHTENING AGENT COMBINING CELL INTRODUCTION PEPTIDE AND SKIN INTRODUCTION ACCELERATOR UPDATE

外国特許コード F130007533
掲載日 2013年7月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP071845
国際公開番号 WO 2013031833
国際出願日 平成24年8月29日(2012.8.29)
国際公開日 平成25年3月7日(2013.3.7)
優先権データ
  • 特願2011-189687 (2011.8.31) JP
発明の名称 (英語) SKIN INTRODUCTION SYSTEM AND LIGHTENING AGENT COMBINING CELL INTRODUCTION PEPTIDE AND SKIN INTRODUCTION ACCELERATOR UPDATE
発明の概要(英語) Provided is a skin introduction system capable of introducing a broad range of drugs efficiently into individual cells of each of the tissues of the skin. Also provided is a lightening agent that provides highly effective lightening using the system. The skin introduction system is characterized in combining a skin introduction accelerator into a peptide derivative obtained by adding to a drug a peptide comprising an amino acid sequence in which 3 to 13 residual groups of arginine are concatenated. The lightening agent includes a peptide derivative of hydroquinone obtained by adding to hydroquinone a peptide comprising an amino acid sequence in which 3 to 13 residual groups of arginine are concatenated, the lightening agent characterized in being combined with a skin introduction accelerator.
従来技術、競合技術の概要(英語) BACKGROUND ART
Specifically absorbed drug transdermally in general as a method, adding the functional group and a lipophilic targeting agents, ester or a surfactant, such as an enzyme reagent used at the same time the chemical absorption facilitation (Patent Document 1) or, non-ionic surfactant, a medium chain aliphatic single glycerin ester, absorption enhancers such as the amide compound or a combination of ultrasound and microneedles (Patent Document 2) formed by small holes such as the stratum corneum by physical absorption or absorption method (patent document 3) facilitation and the like.
However, promote the chemical absorption method, a sufficient effect is currently has not been achieved, in addition, to promote physical absorption method, for introduction into the devices is required, can cause injury to the skin further pointed out.
On the other hand, arginine peptide having the amino acid sequence in a row passes through the biological membrane functions as a signal sequence, a cell-membrane permeable have been reported (patent document 4). However, when applied to the skin, the degree to which the individual cells of the skin tissue and the like are introduced into, not heretofore reported No.
In particular, molecular weight 500Da or more of the compounds or the non-fat-soluble drug skin such as for the introduction, the introduction system includes effective so far not been reported.
In addition, the mechanism of transport is melanin production and melanin, the basic research, as well as applied research for a person, people that is widely and generally non-exhaustive list of interest is constantly in the topic. Ultraviolet rays such as excessive by tanning of the strong stimulation of the tyrosinase is abnormally activated, becomes very high when the melanin synthesis function, cannot be metabolized from the amount of melanin skin left on the skin to reach the base layer. By repeating this for many years, of a blemish at appears.
(Hereinafter, referred to also HQ) hydroquinone is lightening ingredients USA Food and Drug Administration (FDA) but was the only component, skin irritation is very high for more than 4% is required for the prescription of a physician. Therefore, in general commercially available cosmetics blended hydroquinone concentration is much less than the effective concentration, the effect can not be expected.
In addition, at a concentration of the whitening effect in the case of using hydroquinone, 'white' is very white portion referred to as decolorization of the dye becomes mottled can exhibit side effects such as have been reported. This is because, in particular the use of sensitive skin in consideration to a female, a fatal problem point.
Therefore, non-fat-soluble low-molecular-weight compound, various polymer compounds such as proteins more effectively to the skin active ingredient can be introduced to a new system been desired earnestly.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • National University Corporation Okayama University
  • 発明者(英語)
  • MATSUI, Hideki
  • MICHIUE, Hiroyuki
  • ISHIKAWA, Sanae
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

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