SKIN INTRODUCTION SYSTEM AND LIGHTENING AGENT COMBINING CELL INTRODUCTION PEPTIDE AND SKIN INTRODUCTION ACCELERATOR
|Posted date||Jul 16, 2013|
|International application number||2012JP071845|
|International publication number||WO 2013031833|
|Date of international filing||Aug 29, 2012|
|Date of international publication||Mar 7, 2013|
|Title||SKIN INTRODUCTION SYSTEM AND LIGHTENING AGENT COMBINING CELL INTRODUCTION PEPTIDE AND SKIN INTRODUCTION ACCELERATOR|
|Abstract||Provided is a skin introduction system capable of introducing a broad range of drugs efficiently into individual cells of each of the tissues of the skin. Also provided is a lightening agent that provides highly effective lightening using the system. The skin introduction system is characterized in combining a skin introduction accelerator into a peptide derivative obtained by adding to a drug a peptide comprising an amino acid sequence in which 3 to 13 residual groups of arginine are concatenated. The lightening agent includes a peptide derivative of hydroquinone obtained by adding to hydroquinone a peptide comprising an amino acid sequence in which 3 to 13 residual groups of arginine are concatenated, the lightening agent characterized in being combined with a skin introduction accelerator.|
|Outline of related art and contending technology||
Specifically absorbed drug transdermally in general as a method, adding the functional group and a lipophilic targeting agents, ester or a surfactant, such as an enzyme reagent used at the same time the chemical absorption facilitation (Patent Document 1) or, non-ionic surfactant, a medium chain aliphatic single glycerin ester, absorption enhancers such as the amide compound or a combination of ultrasound and microneedles (Patent Document 2) formed by small holes such as the stratum corneum by physical absorption or absorption method (patent document 3) facilitation and the like.
However, promote the chemical absorption method, a sufficient effect is currently has not been achieved, in addition, to promote physical absorption method, for introduction into the devices is required, can cause injury to the skin further pointed out.
On the other hand, arginine peptide having the amino acid sequence in a row passes through the biological membrane functions as a signal sequence, a cell-membrane permeable have been reported (patent document 4). However, when applied to the skin, the degree to which the individual cells of the skin tissue and the like are introduced into, not heretofore reported No.
In particular, molecular weight 500Da or more of the compounds or the non-fat-soluble drug skin such as for the introduction, the introduction system includes effective so far not been reported.
In addition, the mechanism of transport is melanin production and melanin, the basic research, as well as applied research for a person, people that is widely and generally non-exhaustive list of interest is constantly in the topic. Ultraviolet rays such as excessive by tanning of the strong stimulation of the tyrosinase is abnormally activated, becomes very high when the melanin synthesis function, cannot be metabolized from the amount of melanin skin left on the skin to reach the base layer. By repeating this for many years, of a blemish at appears.
(Hereinafter, referred to also HQ) hydroquinone is lightening ingredients USA Food and Drug Administration (FDA) but was the only component, skin irritation is very high for more than 4% is required for the prescription of a physician. Therefore, in general commercially available cosmetics blended hydroquinone concentration is much less than the effective concentration, the effect can not be expected.
In addition, at a concentration of the whitening effect in the case of using hydroquinone, 'white' is very white portion referred to as decolorization of the dye becomes mottled can exhibit side effects such as have been reported. This is because, in particular the use of sensitive skin in consideration to a female, a fatal problem point.
Therefore, non-fat-soluble low-molecular-weight compound, various polymer compounds such as proteins more effectively to the skin active ingredient can be introduced to a new system been desired earnestly.
|Scope of claims||
(In Japanese)請求の範囲 [請求項1]
|IPC(International Patent Classification)||
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
Contact Information for " SKIN INTRODUCTION SYSTEM AND LIGHTENING AGENT COMBINING CELL INTRODUCTION PEPTIDE AND SKIN INTRODUCTION ACCELERATOR "
- Okayama University Intellectual Property Office
- URL: http://www.okayama-u.ac.jp/user/orpc-ehp/index/index.html
- Address: 1-1-1 Tsushima-naka , Kita-ku , Okayama-city, Japan , 700-8530
- Fax: 81-86-251-8961