NOVEL PHOSPHATIDYLINOSITOL-3-KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION

• 特願2011-217378 (2011.9.30) JP

The purpose of the present invention is to provide a novel PI3K inhibitor. The purpose of the present invention is also to provide a substance that combines a PI3K inhibitory effect and an HDAC inhibitory effect. Finally, the present invention further provides a novel anti-cancer pharmaceutical composition containing the substance, in particular an anti-cancer pharmaceutical composition that is effective even against intractable cancer. One embodiment of the present invention is a phosphatidylinositol-3-kinase (PI3K) inhibitor comprising a depsipeptide-class compound represented by formula (1), or a physiologically acceptable salt thereof.

• TOHOKU UNIVERSITY

• SAIJO KEN,
• ISHIOKA CHIKASHI,
• KATOH TADASHI

• A61K  38/00      ペプチドを含有する医療製剤
• A61P  35/00      抗腫瘍剤
• A61P  35/02      白血病に特異的なもの
• A61P  43/00      グループＡ６１Ｐ１／００～Ａ６１Ｐ４１／００に展開されていない特殊な目的の医薬