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ANTI-GAP43 ANTIBODY 新技術説明会

外国特許コード F130007568
掲載日 2013年7月18日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2012JP077163
国際公開番号 WO 2013058388
国際出願日 平成24年10月19日(2012.10.19)
国際公開日 平成25年4月25日(2013.4.25)
優先権データ
  • 特願2011-230577 (2011.10.20) JP
発明の名称 (英語) ANTI-GAP43 ANTIBODY 新技術説明会
発明の概要(英語) Provided are: an anti-GAP43 antibody which is capable of identifying an unphosphorylated threonine residue (T89) at position 89 of mouse GAP43 represented by SEQ ID NO:13 or a phosphorylated threonine residue (pT89) at position 89, and which is capable of specifically detecting growth cones; an anti-GAP43 antibody which is capable of identifying an unphosphorylated serine residue (S96) at position 96 of the mouse GAP43 or a phosphorylated serine residue (pS96) at position 96, and which is capable of specifically detecting growth cones; an anti-GAP43 antibody which is capable of identifying an unphosphorylated threonine residue (T172) at position 172 of the mouse GAP43 or a phosphorylated threonine residue (pT172) at position 172, and which is capable of specifically detecting growth cones; and an immunological analysis method using these anti-GAP43 antibodies.
従来技術、競合技術の概要(英語) BACKGROUND ART
Nerve generation and playback, and reproducing the image (1) development or the nerve cells, nerve cells generated or reproduces correctly extended axons, synaptic correctly formed stage (2) are required. Axons of the nerve cells and reforming occurs at the front end portion, which is highly dynamic growth cone referred to as a fan-shaped structure is present. This growth cones, and the central region (central domain), containing the legs of the lobes and filamentous temporary temporary foot (peripheral domain) and a peripheral region. The growth cones, for synapse formation, filamentous temporary regression of elongation or foot while properly direct axons.
Growth associated protein 43 (neuromodulin) (hereinafter, 'GAP43' is referred.) Is, growth cone was abundant, filamentous temporary decompression and neurite branch of the foot play an important role. GAP43 Is phosphorylated by protein kinase C on the other hand, are dephosphorylated by calcineurin. Functions as a non-phosphorylated GAP43 is cytoplasmic, extension of the foot to reduce filamentous temporary. In addition, the first mouse GAP43 41 (S41) the first phosphorylation of the serine residue, temporary foot for the extension of the filamentous actin and is thought to be important for the stabilization of the (for example, Denny, JB ., Curr Neuropharmacol.,Vol.4 (12): see pp.293-304 (2006)).
Conventional, in order to assess the stage (2) The, GAP43 phosphorylation-recognizing anti-S41 antibody is used.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIIGATA UNIVERSITY
  • 発明者(英語)
  • TAKEUCHI, Kosei
  • IGARASHI, Michihiro
  • NOZUMI, Motohiro
  • KAWASAKI, Asami
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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