DOUBLE-STRANDED NUCLEIC ACID MOLECULE FOR GENE EXPRESSION CONTROL
Provided are an improved double-stranded nucleic acid molecule for gene expression control mediated by gene silencing
a method for producing the same
and a pharmaceutical composition comprising the double-stranded nucleic acid molecule. Provided are a double-stranded nucleic acid molecule for gene expression control, which comprises an antisense chain having the length of 18 to 28 bases and a sense chain including a complementary portion formed from a sequence that is sufficiently complementary to the antisense chain, and at the 5' terminal, a single-stranded projecting portion having the length of 2 to 100 bases, wherein the sense chain and the antisense chain form a base bond via the complementary portion
and a pharmaceutical composition containing the double-stranded nucleic acid component as the active ingredient.