Top > Search of International Patents > Inhibitor of HMGB protein-mediated immune response activation, and screening method

Inhibitor of HMGB protein-mediated immune response activation, and screening method

Foreign code F130007603
File No. AF22-02WO
Posted date Aug 9, 2013
Country China
Application number 201180044442
Gazette No. 103096899
Gazette No. 103096899
Date of filing Sep 14, 2011
Gazette Date May 8, 2013
Gazette Date Jan 28, 2015
International application number JP2011071023
International publication number WO2012036215
Date of international filing Sep 14, 2011
Date of international publication Mar 22, 2012
Priority data
  • 2011JP071023 (Sep 14, 2011) WO
  • P2010-209587 (Sep 17, 2010) JP
  • P2011-138825 (Jun 22, 2011) JP
Title Inhibitor of HMGB protein-mediated immune response activation, and screening method
Abstract Provided is an inhibitor of HMGB protein-mediated immune response activation, comprising one or more compounds selected from the group consisting of phosphorothioate oligonucleotides and derivatives thereof.
Also provided is a method for screening an inhibitor or promoter of HMGB protein-mediated immune response activation, comprising: a mixing step of mixing an HMGB protein and a labeled nucleic acid in the presence and absence of a test substance; a assaying step of assaying the HMGB protein bound to the labeled nucleic acid; and a determination step of determining that the test substance is an inhibitor of HMGB protein-mediated immune response activation in the case that the quantity of the HMGB protein bound to the labeled nucleic acid in the presence of the test substance is less than the quantity of the HMGB protein bound to the labeled nucleic acid in the absence of the test substance, and determining that the test substance is a promoter of HMGB protein-mediated immune response activation in the case that the quantity of the HMGB protein bound to the labeled nucleic acid in the presence of the test substance is greater than the quantity of the HMGB protein bound to the labeled nucleic acid in the absence of the test substance.
  • Applicant
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • Inventor
  • TANIGUCHI TADATSUGU
  • YANAI HIDEYUKI
IPC(International Patent Classification)
Reference ( R and D project ) CREST Etiological Basics of and Techniques for Treatment of Allergic and Autoimmune Diseases AREA
Please contact us by E-mail or facsimile if you have any interests on this patent.

PAGE TOP

close
close
close
close
close
close