NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME
外国特許コード | F130007612 |
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整理番号 | S2012-0300-N0 |
掲載日 | 2013年8月16日 |
出願国 | 世界知的所有権機関(WIPO) |
国際出願番号 | 2013JP051733 |
国際公開番号 | WO 2013/111897 |
国際出願日 | 平成25年1月28日(2013.1.28) |
国際公開日 | 平成25年8月1日(2013.8.1) |
優先権データ |
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発明の名称 (英語) | NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME |
発明の概要(英語) |
The present invention provides a novel antitumor agent with a novel action mechanism. The novel antitumor agent comprises, as the active ingredient, a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein (RhoGAP). The RhoGAP, which depends on the cell cycle, plays an important role in the course of the acquisition of metastatic ability and/or invasive ability by cancer cells. By targeting the RhoGAP, the invasion and/or metastasis of cancer cells can be controlled. As the substance capable of inhibiting the cell cycle-dependent RhoGAP, an antisense oligonucleotide against an RhoGAP-encoding gene, an oligonucleotide inducing RNA interference, etc. can be cited. An oligonucleotide containing a synthetic nucleic acid such as BNA is preferred because of the high stability thereof. The present invention also provides a screening method for selecting an antitumor agent which is capable of suppressing the invasion and/or metastasis of cancer cells by a novel mechanism. This method for screening a novel antitumor agent is characterized in that a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein is selected thereby. |
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国際特許分類(IPC) |
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日本語項目の表示
発明の名称 | 新規抗腫瘍剤及びそのスクリーニング方法 |
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