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NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME

Foreign code F130007612
File No. S2012-0300-N0
Posted date Aug 16, 2013
Country WIPO
International application number 2013JP051733
International publication number WO 2013/111897
Date of international filing Jan 28, 2013
Date of international publication Aug 1, 2013
Priority data
  • P2012-015982 (Jan 27, 2012) JP
Title NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME
Abstract

The present invention provides a novel antitumor agent with a novel action mechanism. The novel antitumor agent comprises, as the active ingredient, a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein (RhoGAP). The RhoGAP, which depends on the cell cycle, plays an important role in the course of the acquisition of metastatic ability and/or invasive ability by cancer cells. By targeting the RhoGAP, the invasion and/or metastasis of cancer cells can be controlled. As the substance capable of inhibiting the cell cycle-dependent RhoGAP, an antisense oligonucleotide against an RhoGAP-encoding gene, an oligonucleotide inducing RNA interference, etc. can be cited. An oligonucleotide containing a synthetic nucleic acid such as BNA is preferred because of the high stability thereof. The present invention also provides a screening method for selecting an antitumor agent which is capable of suppressing the invasion and/or metastasis of cancer cells by a novel mechanism. This method for screening a novel antitumor agent is characterized in that a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein is selected thereby.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • OSAKA UNIVERSITY
  • Inventor
  • ISHII, MASARU,
  • KAGAWA, YOSHINORI,
  • MORI, MASAKI,
  • ISHII, HIDESHI
IPC(International Patent Classification)
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