NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME
|Posted date||Aug 16, 2013|
|International application number||2013JP051733|
|International publication number||WO 2013/111897|
|Date of international filing||Jan 28, 2013|
|Date of international publication||Aug 1, 2013|
|Title||NOVEL ANTITUMOR AGENT AND METHOD FOR SCREENING SAME|
The present invention provides a novel antitumor agent with a novel action mechanism. The novel antitumor agent comprises, as the active ingredient, a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein (RhoGAP). The RhoGAP, which depends on the cell cycle, plays an important role in the course of the acquisition of metastatic ability and/or invasive ability by cancer cells. By targeting the RhoGAP, the invasion and/or metastasis of cancer cells can be controlled. As the substance capable of inhibiting the cell cycle-dependent RhoGAP, an antisense oligonucleotide against an RhoGAP-encoding gene, an oligonucleotide inducing RNA interference, etc. can be cited. An oligonucleotide containing a synthetic nucleic acid such as BNA is preferred because of the high stability thereof. The present invention also provides a screening method for selecting an antitumor agent which is capable of suppressing the invasion and/or metastasis of cancer cells by a novel mechanism. This method for screening a novel antitumor agent is characterized in that a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein is selected thereby.
|IPC(International Patent Classification)||
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