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PROPHYLACTIC OR THERAPEUTIC AGENT FOR BRONCHIAL ASTHMA AND METHOD FOR SCREENING SAME

外国特許コード F130007613
整理番号 S2012-0264-N0
掲載日 2013年8月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP051120
国際公開番号 WO 2013111714
国際出願日 平成25年1月22日(2013.1.22)
国際公開日 平成25年8月1日(2013.8.1)
優先権データ
  • 特願2012-011838 (2012.1.24) JP
発明の名称 (英語) PROPHYLACTIC OR THERAPEUTIC AGENT FOR BRONCHIAL ASTHMA AND METHOD FOR SCREENING SAME
発明の概要(英語) The present invention provides a prophylactic or therapeutic agent for bronchial asthma, said agent comprising a heme peroxidase inhibitor. Thus, a prophylactic or therapeutic agent for bronchial asthma, which has a function mechanism different from the function mechanism of inhaled steroids and is usable as a substitute for inhaled steroids, is provided.
従来技術、競合技術の概要(英語) BACKGROUND ART
Is bronchial asthma, airway hyper-responsiveness to nonspecific stimulator upregulation is indicative of the disease and, coughing, sputum, dyspnea such clinical symptoms as cause disease. The therapeutic agent is used in the treatment of bronchial asthma agent is mainly an inhaled steroid, the leukotriene receptor antagonists, β 2 receptor stimulants, theophylline and the like which are used in combination.
Bronchial asthma with respect to the effectiveness of the high inhaled steroid, steroid 10-15% of all patients with bronchial asthma patients show resistance, high resistance to such steroids and additives other than for patients in the treatment of an inhaled steroid drug is required. In addition, in children such as bronchial asthma patients who, from the viewpoint of the use of an inhaled steroid side effects sometimes where the width.
For this reason, the pharmacological effects of an inhaled steroid agent which is quite different, bronchial asthma can be inhaled steroid agent instead of the development of therapeutics has been desired.
However, thiamazole is, so far as therapeutic agents against hyperthyroidism and been widely used, and safety thereof has been confirmed (non-patent document 1).
In addition, the non-patent document 2, the major side effects of the blood cells as thiamazole, arthritis multiple sclerosis are known, the frequency is very low and less than 1%, the appearance of symptoms such as eczema skin itch even minor degree which, in non-patent document 3, the spermatogonia and spermatocytes thiamazole, as well as bone marrow cells does not cause chromosomal abnormalities have been described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SAGA UNIVERSITY
  • 発明者(英語)
  • IZUHARA Kenji
  • ARIMA Kazuhiko
  • SUZUKI Shoichi
  • SHIRAISHI Hiroshi
  • OHTA Shoichiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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