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COLLAGEN-LIKE PEPTIDE HAVING STEALTH PROPERTY AND HIGH URINARY EXCRETION PROPERTY

外国特許コード F130007614
整理番号 S2012-0325-N0
掲載日 2013年8月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP051244
国際公開番号 WO 2013111759
国際出願日 平成25年1月23日(2013.1.23)
国際公開日 平成25年8月1日(2013.8.1)
優先権データ
  • 特願2012-011029 (2012.1.23) JP
発明の名称 (英語) COLLAGEN-LIKE PEPTIDE HAVING STEALTH PROPERTY AND HIGH URINARY EXCRETION PROPERTY
発明の概要(英語) The purpose of the present invention is to develop a drug carrier having a stealth property and a high urinary excretion property. The present invention provides: a collagen-like peptide which is a drug carrier having a stealth property and a high urinary excretion property; and a pharmaceutical composition containing the collagen-like peptide. In the pharmaceutical composition, a drug or a biologically active group is bound to the collagen-like peptide. Therefore, the pharmaceutical composition can be used for the detection, diagnosis or the like of a biological function or a biological condition. When a drug or a biologically active group which is responsive to oxidative stress in a living body is bound to the collagen-like peptide of the present invention, the collagen-like peptide may be used for the detection or diagnosis of oxidative stress occurring in radiation damages, fulminant hepatitis, anaphylactic shock, atherosclerosis, angina pectoris, cardiac infarction, Alzheimer's disease or Parkinson's disease. The pharmaceutical composition of the present invention may be a magnetic resonance imaging agent.
従来技術、競合技術の概要(英語) BACKGROUND ART
Delivering the drug to a target organ or, in order to control the kinetics of the drug in the body of the development of drug-delivery system, drug discovery important area to one field of the form. So far, liposomes, dendrimers, supramolecular peptide, such as a drug carrier seat of inorganic nanoparticles is the overlaid two substrates have been developed (non-patent document 1-4). In general, relatively large size of these drug carrier is trapped in the reticuloendothelial system cells, easily upon decomposition. On the other hand, is treated with a drug carrier that modify the surface, trapped in the reticuloendothelial system cells can be reduced. Drug carrier for stealth property is, trapped in the reticuloendothelial system cells is hard. For example, to a predetermined size by the surface of the liposomes modified with polyethylene glycol, stealth property liposomes can be generated. However, the glomeruli of the kidney is a radio wave stealth property such liposomes which are filtered off from the size is too large, low urinary excretion (non-patent document 5-7). Of the use of drugs in patients with renal impairment, or, in the use of medicine or the normal diagnosis, residence in a living body for a long time after administration to elicit adverse effects there is a possibility. A stealth property, and, in the urine excretion of the drug carrier is now likely has not been known to date.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • WASEDA UNIVERSITY
  • 発明者(英語)
  • KOIDE, Takaki
  • YAMAZAKI, Chisato
  • YASUI, Hiroyuki
  • TAKAO, Toshifumi
  • AWADA, Chihiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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