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NOVEL ANTI-MALIGNANT TUMOR AGENT

Foreign code F130007616
File No. S2012-0313-N0
Posted date Aug 16, 2013
Country WIPO
International application number 2013JP051275
International publication number WO 2013/111770
Date of international filing Jan 23, 2013
Date of international publication Aug 1, 2013
Priority data
  • P2012-010580 (Jan 23, 2012) JP
Title NOVEL ANTI-MALIGNANT TUMOR AGENT
Abstract

The present invention provides an anti-tumor agent which is a molecular targeted drug for a malignant tumor and is highly safe. An anti-malignant tumor agent characterized by comprising, as an active ingredient, a substance capable of targeting a ribosome protein of which the expression is increased in a malignant tumor cell. The substance capable of targeting a ribosome protein of which the expression is increased in a malignant tumor cell according to the present invention is considered as a substance involved in a biological defense mechanism that is believed to be provided intrinsically in a living body and can prevent the development of diseases even if a cancer cell is generated. Specifically, the ribosome protein of which the expression is increased is RPL29 and/or RPS4X. A substance capable of targeting RPL29 and/or RPS4X is an anti-RPL29 antibody and/or an anti-RPS4X antibody, a substance capable of activating or enhancing an endogenous anti-RPL29 antibody and/or an endogenous anti-RPS4X antibody occurring in a living body, a substance capable of inducing the production of an anti-RPL29 antibody and/or an anti-RPS4X antibody in a living body, or an antagonist of RPL29 and/or RPS4X. The present invention also provides a method for testing an malignant tumor, in which an anti-RPL29 antibody titer and/or an anti-RPS4X antibody titer is employed as a measure.

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • Inventor
  • MIYAKE, YASUHIRO,
  • YAMAMOTO, KAZUHIDE
IPC(International Patent Classification)

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