CYCLIC PEPTIDE COMPOUND OR PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF AND METHOD FOR PRODUCING SAME
Provided are a cyclic peptide compound or a pharmacologically acceptable salt thereof capable of inhibiting parakeratosis of skin, and a method for producing the same. This method comprises subjecting a cyclic peptide compound of Formula (I): or a pharmacologically acceptable salt thereof, wherein Xaa 1 and Xaa 5 are each optionally substituted Ser, optionally substituted Thr, or optionally substituted Tyr
Xaa 2 is optionally substituted Ile, optionally substituted Val, or optionally substituted Leu
Xaa 3 and Xaa 4 are each optionally substituted Asn, optionally substituted Gln, optionally substituted Asp, or optionally substituted Glu
and R 1 is a group of Formula (II): -CO-(CH 2 ) n -NH- (II) or Formula (III): -NR-(CH 2 ) n -CO- (III) wherein n is the same as defined above, and in Formula (I), the linkage between Cys and Cys is a peptide bond or a disulfide bond, and the other linkages are peptide bonds, to cyclization with a compound of Formula (IV): Cys-R 1 -Xaa 1 -Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Cys (IV) wherein, Xaa 1 , Xaa 2 , Xaa 3 , Xaa 4 , Xaa 5 , and R 1 are the same as defined above.