METHOD FOR PREDICTING RISK OF PORENCEPHALY OR CEREBRAL HEMORRHAGE
A screening was made intensively on the mutation of COL4A2 gene in 35 Japanese porencephaly patients. As a result, it was found that COL4A2 gene is a causal gene for familial and sporadic porencephaly. An identical hetero mutation of COL4A2 gene was observed in both porencephaly patients and normal persons, and the pathogenic mutation is considered as a dominant inheritance with incomplete penetrance. It can be predicted that a living organism having a COL4A2 gene mutation has a high risk of the occurrence of porencephaly or cerebral hemorrhage.