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NEURONAL DIFFERENTIATION PROMOTER UPDATE

外国特許コード F130007784
整理番号 S2012-0683-N0
掲載日 2013年12月16日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP062490
国際公開番号 WO 2013162027
国際出願日 平成25年4月26日(2013.4.26)
国際公開日 平成25年10月31日(2013.10.31)
優先権データ
  • 特願2012-103875 (2012.4.27) JP
発明の名称 (英語) NEURONAL DIFFERENTIATION PROMOTER UPDATE
発明の概要(英語) The present invention provides a neuronal differentiation promoter for a neural stem cell, which comprises a p38 inhibitor. The present invention also provides a method for promoting the neuronal differentiation of a neural stem cell, which comprises culturing the neural stem cell in the presence of a p38 inhibitor. The neural stem cell is of a gliogenesis type of a neurogenesis type. The p38 inhibitor is a nucleic acid that can hybridize with DNA encoding p38 or mRNA for the DNA under physiological conditions to inhibit the transcription and/or translation of the DNA or the mRNA, an expression vector for the nucleic acid, a low-molecular-weight p38 inhibitor or the like.
従来技術、競合技術の概要(英語) BACKGROUND ART
Central nervous system (CNS) injury and disease, new modern medicine has attracted attention. Induced pluripotent stem cells (iPSC) technology typified by recent advances in stem cell biology, personalized medicine and transplantation for screening of innovative as a source of interest with a stem cell. Having a multipotent neural stem cells (NSCs) is, all types of nerve cells in the CNS occurs, this is now can be easily obtained from iPSCs. However, the target cell population NSCs uniformly or at specific and efficient, and to control differentiation NSC for complex mechanisms, remains still difficult. Therefore, a particular cell type from which produces NSCs identified further means, in order to facilitate the therapeutic applications are for development.
The inventors of the present invention, the molecular mechanism responsible for differentiation NSC to study, under development in recent years derived from embryonic stem cells (ESC) used culture system in which the new microspheres (non-patent document 1, patent document 1). Is NSCs, to differentiate into neurons and glial cells has a pluripotent, generated during the course of the vertebrate CNS, neural differentiation is glial differentiation is significantly less than the ahead. This neural differentiation from glial differentiation switch, the transition time of the required specificity (temporal identity transition) NSCs (non-patent document 2). Importantly, the present inventors developed the new microsphere culture system, the transitions over time in vivo neuronal regeneration can be reproduced. Using this system, the inventors of the present invention II Coup-tfI and (Coup-tfs; Nr2f1 and also known as Nr2f2.) Is, for a period of time specificity NSCs critical transition previously found to act as a molecular switch (non-patent document 1, patent document 1).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • KEIO UNIVERSITY
  • RIKEN
  • 発明者(英語)
  • KANEDA, Hayato
  • OKANO, Hideyuki
  • SHIMAZAKI, Takuya
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
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