TOP > 外国特許検索 > OLIGOSACCHARIDE SYNTHETASE MANNOSYL-Β-1,4-N-ACETYLGLUCOSAMINE PHOSPHORYLASE AND METHOD FOR PRODUCING CORE SUGAR CHAIN STRUCTURE OF ASPARAGINE-LINKED GLYCOPROTEIN

OLIGOSACCHARIDE SYNTHETASE MANNOSYL-Β-1,4-N-ACETYLGLUCOSAMINE PHOSPHORYLASE AND METHOD FOR PRODUCING CORE SUGAR CHAIN STRUCTURE OF ASPARAGINE-LINKED GLYCOPROTEIN

外国特許コード F140007958
整理番号 S2012-0932-C0
掲載日 2014年9月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP068549
国際公開番号 WO 2014034274
国際出願日 平成25年7月5日(2013.7.5)
国際公開日 平成26年3月6日(2014.3.6)
優先権データ
  • 特願2012-190474 (2012.8.30) JP
発明の名称 (英語) OLIGOSACCHARIDE SYNTHETASE MANNOSYL-Β-1,4-N-ACETYLGLUCOSAMINE PHOSPHORYLASE AND METHOD FOR PRODUCING CORE SUGAR CHAIN STRUCTURE OF ASPARAGINE-LINKED GLYCOPROTEIN
発明の概要(英語) [Problem] To efficiently produce a core sugar chain structure of an asparagine-linked glycoprotein.
[Solution] A method for easily producing in a single step a core sugar chain structure of an asparagine-linked glycoprotein, said core sugar chain structure being mannosyl-β-1,4-N-acetylglucosamine or mannosyl-β-1,4-kitobiose, through an oligosaccharide synthesis reaction that is catalyzed by mannosyl-β-1,4-N-acetylglucosamine phosphorylase with the use of, as the starting materials, α-mannose 1-phosphate together with N-acetylglucosamine or kitobiose.
従来技術、競合技術の概要(英語) BACKGROUND ART
A glycoprotein sugar chain biometric recognition (cell adhesion, antigen-antibody reaction, information transmission, virus infection) for the importance of attention in recent years is to gather at the location. Sugar chain, nucleic acid, followed by the third strand of said protein, its function in the recent years has been elucidated. Among them, asparagine-linked type sugar chain, protein binding, cell differentiation, aging, such as a biological phenomenon or an immune response, cancer, viral infection, inflammatory diseases such as deep is known. Further, the elucidation of sugar chain functions at the molecular level, is a sugar chain using further drug discovery is expected to be applied to.
However, the amount of expression of in vivo sugar chain sample preparation consisted of a small amount of organic synthetic methods inevitable to again depend on the current, the difficulty glyco-engineering research areas and sugar chain are and progress of regenerative medicine. For example, asparagine-linked type sugar is 3, in the prior art, complicated multi-stage reaction in organic synthesis method is produced (patent document 1), a large amount that it is difficult to efficiently prepared, extremely expensive problem was. Therefore, the establishment of a simple manufacturing method to which a sugar chain is urgently needed.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIIGATA UNIVERSITY
  • 発明者(英語)
  • NAKAI, Hiroyuki
  • NIHIRA, Takanori
  • SUZUKI, Erika
  • OHTSUBO, Kenichi
  • KITAOKA, Motomitsu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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