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METHOD FOR TESTING FOR NEPHRITIS-LESION SITES AND REAGENT THEREFOR

Foreign code F140008029
File No. S2012-0910-C0
Posted date Nov 19, 2014
Country WIPO
International application number 2013JP080296
International publication number WO 2014073653
Date of international filing Nov 8, 2013
Date of international publication May 15, 2014
Priority data
  • P2012-247896 (Nov 9, 2012) JP
Title METHOD FOR TESTING FOR NEPHRITIS-LESION SITES AND REAGENT THEREFOR
Abstract A method and the like in which an FSP1-specific antibody is used to measure and compare multimeric FSP1 and monomeric FSP1.
Outline of related art and contending technology BACKGROUND ART
FSP1 Is, a specific marker of fibroblasts was identified as a (non-patent document 1) is a protein, a protein pair EF hand domain encoding filament binding S100A4 (Non-Patent Document 2). The present inventors, of the crescent forming glomerulonephritis in glomerular disease activity, and somatic cells of the podocyte-moon is found that the expression of FSP1 (non-patent document 3), forming a crescent glomerulonephritis in urine of patients FSP1 that can serve as a biomarker of the disease is found (Non-Patent Document 4). In addition, cellular crescent formation FSP1 in the urine of the glomeruli in the art will recognize the frequency of appearance of each of which shows a positive correlation, an indicator of disease activity also found. However, FSP1 and the kidney disease in a biological sample have been demonstrated to be relevant to the formation of the meniscus remains glomerulonephritis, interstitial renal disease is still in a biological sample FSP1 but no report association. In addition, in patients with renal lesion in a simple and also a method of determining the clinical practice is still a need for development.
Scope of claims (In Japanese)請求の範囲 [請求項1]
 以下の工程を含むことを特徴とする、腎炎の病変部位を判定するための検査方法:
(1)被験者由来の生体試料における総FSP1濃度、単量体FSP1濃度および多量体FSP1濃度のうちいずれか2つ以上を測定する工程、
(2)被験者由来の生体試料における単量体FSP1濃度および多量体FSP1濃度を比較する工程。

[請求項2]
 生体試料が尿試料であることを特徴とする、請求項1に記載の検査方法。

[請求項3]
 総FSP1濃度、単量体FSP1濃度および多量体FSP1濃度の測定が、免疫化学的測定法によって測定されることを特徴とする、請求項1または2に記載の検査方法。

[請求項4]
 判定される腎炎の病変部位が、糸球体または間質組織である請求項1~3のいずれか1項に記載の検査方法。

[請求項5]
 FSP1特異的抗体を、少なくとも1種類含む、腎炎の病変部位を判定するための試薬。

[請求項6]
 判定される腎炎の病変部位が、糸球体または間質組織である請求項5に記載の試薬。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF FUKUI
  • DS PHARMA BIOMEDICAL CO., LTD.
  • Inventor
  • IWANO, Masayuki
  • FUNAOKA, Hiroyuki
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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