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PROTOZOAN PROTEIN PERTAINING TO PLASMODIUM INFECTION IN LIVER STAGE

外国特許コード F140008039
整理番号 S2014-1045-N0
掲載日 2014年12月4日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP082139
国際公開番号 WO 2014084333
国際出願日 平成25年11月29日(2013.11.29)
国際公開日 平成26年6月5日(2014.6.5)
優先権データ
  • 特願2012-261832 (2012.11.30) JP
発明の名称 (英語) PROTOZOAN PROTEIN PERTAINING TO PLASMODIUM INFECTION IN LIVER STAGE
発明の概要(英語) The present invention addresses the problem of identifying a protein essential for plasmodium in a liver-infection stage to proceed to the next stage, pro viding a test method for searching for a compound obstructing this prote in, and providing a compound for hindering infection with plasmodium by obstructing the protein. The objective is achieved by a method of testing a subst ance for hindering infection with plasmodium, the test method being characterized in that an evaluation is made of whether or not merozoite formation in a liver stage of infection with plasmodium is obstructed by restraining action of LS-specific protein 2 (LISP2) in which plasmodium is specifically ex pressed in host cells in the middle to the latter period of the liver stage.
従来技術、競合技術の概要(英語) BACKGROUND ART
About 5 million malaria cases per year and about 200 million of deaths of infected persons issues, HIV, tuberculosis infection a line with the large 3 is one of the world. The current, the global spread of drug-resistant protozoa and it is difficult to treated. That is, almost all of antimalarial drugs (chloroquine, mefloquine, and the like fanshi dahl) is spread and resistance to protozoa, and the effectiveness. Liver stage infection (liver stage (LS) ) is, when the human malaria parasite in the first stage of the parasitic. Malaria mosquito infested P. and placement into the human being, injected into the intradermal liverstage. After moving to the liver liverstage, parasitic vesicles formed in hepatocytes (parasitophorous vacuole(PV) ) penetrate, proceeds to liver stage infection. The liver stage malaria parasite infection, eventually changes to several thousands of merozoite, after being released into the blood, infected red blood cells. Liver cells in malaria parasite infection for the first line of defense. Liver cells have (Bongfen et al., 2007 malaria parasite infection immune system; Chakravarty et al., 2007; Cockburn et al., 2011: prior art document will be, at the end are shown together.), Cytokines such as TNF-α interferon or responds to, it is possible to eliminate the malaria parasite cells known (Depinay et al., 2011). In addition, infested liver cells, apoptosis is caused, it is possible to suppress spread of the erythrocytes also known (van de Sand et al., 2005). Falciparum malaria infection and the time between the host hepatocytes are deemed to be a dynamic interaction. However, infection of the liver stage malaria parasite is the interaction of liver cells, very little is known about not. In particular, a malaria parasite in the host cell to maintain the infection mechanism, and for the same gene essential for this, many of which remains unknown.
Infection in humans the most serious effect on the parasitic within Plasmodium falciparum when red blood cells, red blood cells of the host from the malaria parasite to be delivered to many proteins known (Maier et al., 2009; Crabb et al., 2010; Haase & de Koning-Ward, 2010). These proteins, modified red blood cells in a variety of ways, internal environment thereof is varied to suit the malaria parasite. In addition, these proteins, the hump-like structure on the surface of red blood cells those involved in the formation (Moxon et al., 2011), mauers, dyad (Maurer's clefts) to be referred to as those involved in the formation (Lanzer et al., 2006 structure; Tilley et al., 2008; Sam-Yellowe, 2009), to the cytoplasm of the host protein to transport important protozoa and the like. These proteins are also, in order to obtain nutrients from the host cell is also an important serves to thought (Maier et al., 2008). On the other hand, for the liver stage malaria parasite infection, transport protein in the host hepatocytes clear indication data is not obtained.
Major surface protein of the sporozoite protein Circumsporozoite (CS), transported to the cytoplasm of the hepatocytes of the malaria parasite proteins known as the only. CS protein, after a few hours from the ingress liverstage, observed in the cytoplasm of hepatocytes (Khan et al., 1992; Singh et al., 2007; Cockburn et al., 2011). However, also be produced by the liver stage malaria parasite infection of gaming (Singh et al., 2007) is unknown. In addition, liver stage malaria parasite late mid produced by infection, the protein transport in the cytoplasm of liver cells is not known.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • MIE UNIVERSITY
  • 発明者(英語)
  • YUDA, Masao
  • IWANAGA, Shiroh
  • KANEKO, Izumi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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