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PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND/OR PREVENTION OF DISEASE INVOLVING ABNORMAL ACCUMULATION OF AMYLOID β PROTEIN UPDATE

外国特許コード F150008064
整理番号 S2013-0314-C0
掲載日 2015年1月8日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP083435
国際公開番号 WO 2014097978
国際出願日 平成25年12月13日(2013.12.13)
国際公開日 平成26年6月26日(2014.6.26)
優先権データ
  • 特願2012-277068 (2012.12.19) JP
発明の名称 (英語) PHARMACEUTICAL COMPOSITION FOR THE TREATMENT AND/OR PREVENTION OF DISEASE INVOLVING ABNORMAL ACCUMULATION OF AMYLOID β PROTEIN UPDATE
発明の概要(英語) Provided is a pharmaceutical composition for the treatment and/or prevention of disease involving the abnormal accumulation of amyloid β protein, which contains ILEI or a vector in which the polynucleotide encoding ILEI has been inserted. Also provided are a method for screening for compounds for the treatment and/or prevention of disease involving abnormal accumulation of amyloid β protein, as well as a method for the treatment and/or prevention of disease involving the abnormal accumulation of amyloid β protein.
従来技術、競合技術の概要(英語) BACKGROUND ART
Protein (A β) β aminoid abnormal accumulation in the brain, and of molecular pathological Alzheimer's disease (AD), reduce A β for the treatment of a pathologic condition may be based on expected.
A β amyloid β precursor protein in neuronal cells (APP) by proteolysis of the producing stage 2. In the vicinity of the cell membranes in the β secretase cleavage of the first (β-secretase) catalyzed by, the external domain N-terminus of a secreted form of the transmembrane C-terminal fragment (sAPP β) (APP-CTFβ or APP-C99) production. Then, in the film γ secretase (γ-secretase) aspartyl protease (the next 4 macromolecule complexes one core components: presenilin, nicastrin, anterior pharynx defective-1 (APH-1), presenilin enhancer-2 (PEN-2) ) is, and the intracellular domain A β APP APP-C99(AICD) (see Fig. 4) to decompose. In the degradation of the other APP-C99, does not produce path A β also known.
In the development of strategies for treatment of Alzheimer, from APP as a method for decreasing the production A β, γ secretase inhibitors of the activity of conventional mainly have been used. Many inhibitors have been developed, in the group administered with γ secretase inhibitors thereof, from the results of clinical trials of the accumulation of intracellular APP-C99, and cleavage of the protein and a substrate along with APP Notch as a side effect presumably due to the failure of dementia exacerbation of the skin increases the frequency of cancer onset proved to be observed.
Patent Document 1 is one of the biomarkers of Alzheimer's disease have been reported. Specifically, qualitative status of Alzheimer's disease in a subject for the method of the invention related to, the method includes, in a biological sample from the subject (a) at least one biomarker measured in step 1 a, the at least one biomarker is 1, saposins D (I), (II) saposins D, saposins D (I) and FAM3C (III) is selected from, step; Alzheimer's disease as well as the measurement results of (b) the step of associating state, characterized in that it comprises.
However, in Patent Document 1, one protein 4 used as a biomarker of Alzheimer's disease can only be described, for other applications is not described.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • SHIGA UNIVERSITY OF MEDICAL SCIENCE
  • 発明者(英語)
  • NISHIMURA, Masaki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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