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β-SUBSTITUTED-β-TRIFLUOROMETHYL-α,β-EPOXYKETONE COMPOUND HAVING ASYMMETRIC QUATERNARY CARBON, AND METHOD FOR PRODUCING SAME

Foreign code F150008093
Posted date Jan 23, 2015
Country WIPO
International application number 2013JP070772
International publication number WO 2014024753
Date of international filing Jul 31, 2013
Date of international publication Feb 13, 2014
Priority data
  • P2012-174674 (Aug 7, 2012) JP
Title β-SUBSTITUTED-β-TRIFLUOROMETHYL-α,β-EPOXYKETONE COMPOUND HAVING ASYMMETRIC QUATERNARY CARBON, AND METHOD FOR PRODUCING SAME
Abstract [Problem] To provide a β-substituted-β-trifluoromethyl-α,β-epoxyketone compound having an asymmetric quaternary carbon, and a method for producing same. [Solution] The target compound represented by general formula (1) can be obtained by means of a highly-enantioselective epoxidation reaction on a β-substituted-β-trifluoromethyl enone by using a cinchona alkaloid phase-transfer catalyst and methylhydrazine, and by using molecular oxygen as the oxidative agent. (Claim 1 sets for the definitions for R1, R2 and R3 in the formula.)
Scope of claims (In Japanese)[請求項1]
下記一般式(1)で表される不斉四級炭素を有するβ-置換-β-トリフルオロメチル-α、β-エポキシケトン化合物。
[化1]
(式中、R1、R2およびR3は、互いに独立して、水素、アルキル基、アルケニル基、アルキニル基、アラルキル基またはアリール基を示す。)
[請求項2]
下記一般式(2)で表されるβ-置換-β-トリフルオロメチルエノンと、メチルヒドラジンとを、溶媒中、塩基、触媒量のシンコナアルカロイド相間移動触媒および分子状酸素の存在下で、反応させることを特徴とする請求項1に記載の不斉四級炭素を有するβ-置換-β-トリフルオロメチル-α、β-エポキシケトン化合物の製造方法。
[化2]
(式中、R1、R2およびR3は、前記一般式(1)と同じである)
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • NAGOYA INSTITUTE OF TECHNOLOGY
  • Inventor
  • SHIBATA NORIO
  • KAWAI HIROYUKI
  • OKUSU SATOSHI
  • TOKUNAGA ETSUKO
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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