TOP > 外国特許検索 > CELL PROLIFERATION REGULATION COMPOSITION CONTAINING PEPTIDE COMPRISING PARTIAL AMINO ACID SEQUENCE FOR BBF2H7 (BBF2 human homologue on chromosome7) OR ANTIBODY CAPABLE OF BINDING TO SAID PEPTIDE

CELL PROLIFERATION REGULATION COMPOSITION CONTAINING PEPTIDE COMPRISING PARTIAL AMINO ACID SEQUENCE FOR BBF2H7 (BBF2 human homologue on chromosome7) OR ANTIBODY CAPABLE OF BINDING TO SAID PEPTIDE

外国特許コード F150008097
掲載日 2015年1月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP072964
国際公開番号 WO 2014034700
国際出願日 平成25年8月28日(2013.8.28)
国際公開日 平成26年3月6日(2014.3.6)
優先権データ
  • 特願2012-189369 (2012.8.30) JP
発明の名称 (英語) CELL PROLIFERATION REGULATION COMPOSITION CONTAINING PEPTIDE COMPRISING PARTIAL AMINO ACID SEQUENCE FOR BBF2H7 (BBF2 human homologue on chromosome7) OR ANTIBODY CAPABLE OF BINDING TO SAID PEPTIDE
発明の概要(英語) Provided are: a cell proliferation regulation composition which contains a peptide comprising a partial amino acid sequence for BBF2H7 or an antibody capable of binding to the peptide; and others. The problem can be solved by preparing a peptide that comprises a partial amino acid sequence for BBF2H7 and has a cell proliferation activity and an antibody against the peptide.
従来技術、競合技術の概要(英語) BACKGROUND ART
Many of the protein synthesized in the endoplasmic reticulum in the cells, in the correct form to be folded to obtain normal function. However, various abnormal cells and exposed to the environment, biological function of the failure in the endoplasmic reticulum, incomplete protein to the endoplasmic reticulum produced in large quantities. Cells in this unusual situation and have a protein sensor that senses a, repair and degradation of abnormal proteins provide a system for actively driven to protect the cell from toxicity of abnormal proteins. As a protein involved in this mechanism, BBF2H7 is reported (non-patent document 1). BBF2H7 Contributes to the formation of cartilage and it is suggested that, in BBF2H7 deficient mice of the chondrocytes, cartilage matrix protein is not secreted outside the cell to accumulate within the endoplasmic reticulum have been reported (non-patent document 2). In addition, BBF2H7 is indispensable for the formation of transport vehicles Sec23a that promotes the synthesis of the protein has been reported (non-patent document 2). Further, in the film BBF2H7 is cut by Site-1 protease have been reported to receive (regulated intramembrane proteolysis) (non-patent document 3). On the other hand, abnormality of hedgehog signaling has been reported in a variety of cancers, such cancer is example, basal cell carcinoma, neuroectodermal tumor such as neuroblastoma, meningioma, hemangioma, glioblastoma, pancreatic adenocarcinoma, squamous lung cancer, small cell lung cancer, non-small cell lung cancer, chondrosarcoma, breast cancer, rhabdomyosarcoma, esophageal cancer, gastric cancer, biliary cancer, renal cancer, thyroid cancer and the like has been reported (Patent Document 1) are. In fact, vismodegib hedgehog signaling is to inhibit, such as the United States in basal cell carcinoma and have been approved as a therapeutic agent.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • HIROSHIMA UNIVERSITY
  • 発明者(英語)
  • IMAIZUMI, Kazunori
  • SAITO, Atsushi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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