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HUMAN ANTIBODY κ TYPE LIGHT CHAIN COMPLEX-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME 新技術説明会

外国特許コード F150008157
整理番号 AF12-18WO
掲載日 2015年3月17日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP071379
国際公開番号 WO 2015025786
国際出願日 平成26年8月13日(2014.8.13)
国際公開日 平成27年2月26日(2015.2.26)
優先権データ
  • 特願2013-170414 (2013.8.20) JP
発明の名称 (英語) HUMAN ANTIBODY κ TYPE LIGHT CHAIN COMPLEX-CONTAINING COMPOSITION AND METHOD FOR PRODUCING SAME 新技術説明会
発明の概要(英語) This human antibody κ type light chain complex-containing composition comprises a complex in which a human antibody κ type light chain is bound to one type or more of a metal ion selected from the group consisting of Group 10 elements, Group 11 elements and Group 12 elements. The human antibody κ type light chain is a dimer, cysteines at the C terminal of the two human antibody κ type light chains are bound via the metal ion, and 0.1 mol or more of the metal ion is bound per 1 mol of the human antibody κ type light chain.
従来技術、競合技術の概要(英語) BACKGROUND ART
Antibodies, heavy chain (H chain: Heavy chain) from the heavy and light chain (L chain: Light chain) configured. Heavy chain and light chains, variable regions and constant regions (VR: Variable Region) composed of (CR: Constant Region) and, the variable region, hypervariable region (CDR: has Complimentarity Determining Region). Further, the light chain of the antibody, and classified into λ κ type.
In recent years, the antibody with the enzyme-like activity, i.e., antibody enzyme is attracting attention. Antibody enzyme, enzymatically active antibody to recognize both a high molecular weight for, medical, chemical industry, such as in the food industry, and a method of manufacturing are expected to be applied. In particular, high specificity to the target molecule, and cytotoxic for a target molecule by the enzymatic activity can be achieved in the antibody enzyme, with fewer side effects can be expected to have superior anti-cancer agent is. Type of enzyme is particularly a human, upon administration to a human body of expected for fewer side effects, and the like and overseas pharmaceutical company, a human antibody is a useful enzyme in the awaited to be developed.
The present inventors have, heretofore, various of the inventive antibody to an enzyme has been studies were performed to determine (for example, see Patent Document 1). Among them, in Patent Document 2, anti-viral activity against influenza virus and rabies virus is a human antibody having human antibody κ light chain type enzyme reported.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • UDA Taizo
  • HIFUMI Emi
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
参考情報 (研究プロジェクト等) CREST Establishment of Innovative Manufacturing Technology Based on Nanoscience AREA
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