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Aβ PEPTIDE OXIDANT 新技術説明会

外国特許コード F150008167
整理番号 E112P03WO
掲載日 2015年3月18日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP065749
国際公開番号 WO 2014200091
国際出願日 平成26年6月13日(2014.6.13)
国際公開日 平成26年12月18日(2014.12.18)
優先権データ
  • 特願2013-125797 (2013.6.14) JP
  • 特願2013-239622 (2013.11.20) JP
発明の名称 (英語) Aβ PEPTIDE OXIDANT 新技術説明会
発明の概要(英語) Provided are an agent for inhibiting the aggregation and an agent for lowering the toxicity of Aβ peptide, as well as an agent for the prevention and treatment of Alzheimer's disease. An Aβ oxidant that oxidizes one or more amino acid residues that constitute Aβ peptide (excluding an Aβ oxidant that oxidizes only Met).
従来技術、競合技術の概要(英語) BACKGROUND ART
Alzheimer's disease is degeneration of nerve cells, senile plaques and falling off the formation of the pathological features of neurofibrillary tangles has disease is a neurodegenerative disease. Alzheimer's disease is memory, recognition, thinking, it is determined that there is a progressive loss of cognitive symptoms such as cause, eventually leading to death. Deposited into the brain and is the main material constituting the senile plaques is the amyloid β peptide (peptide A β) and, consisting of 39-43 amino acids. A β peptide is cytotoxic cells, which are thought to be caused by Alzheimer's disease (non-patent document 1) are. A β peptide is mainly secreted from the one or amino acids 40 and 42 can be a polypeptide, in particular 42 peptide consists of the aggregation ability of early A β in the brain can be deposited, has a strong cytotoxicity (non-patent document 2) are known. On the other hand, in the case of performing the heating operation, the indoor heat exchanger functions as a condenser, the outdoor heat exchanger functions as an evaporator. A β peptide production as an agent that inhibits, and β - secretase peptide-producing enzyme A β γ - secretase with an agent that inhibits is studied. In addition, the peptide A β peptide antibodies and anti-A β enzyme promoter, such as a drug further A β peptide aggregation is studied.
On the other hand, the oxidant Met A β peptide (A β peptide Met residues of the sulfur atom is oxidized with an oxidant (O) ) can be present in small quantities within a living body, and the agglomerates as compared to an oxidant may be Met A β peptide has been reported to have low (non-patent document 3-5).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • JAPAN SCIENCE AND TECHNOLOGY AGENCY
  • 発明者(英語)
  • KANAI, Motomu
  • SOMA, Yohei
  • TANIGUCHI, Atsuhiko
  • SASAKI, Daisuke
国際特許分類(IPC)
参考情報 (研究プロジェクト等) ERATO KANAI Life Science Catalysis AREA
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