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IDENTIFICATION OF TRANSPORTER RESPONSIBLE FOR CHEMICAL TRANSMISSION OF POLYAMINE AND USE THEREOF

外国特許コード F150008172
掲載日 2015年3月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP006488
国際公開番号 WO 2014068991
国際出願日 平成25年11月1日(2013.11.1)
国際公開日 平成26年5月8日(2014.5.8)
優先権データ
  • 特願2012-243730 (2012.11.5) JP
発明の名称 (英語) IDENTIFICATION OF TRANSPORTER RESPONSIBLE FOR CHEMICAL TRANSMISSION OF POLYAMINE AND USE THEREOF
発明の概要(英語) The present invention relates to the field of a novel polyamine transporter. According to the present invention, a transporter that carries out polyamine transport and a gene that encodes the same are identified. In addition, according to the present invention, a screening method for a polyamine transporter activity modulating agent that uses the transporter and an artificial membrane including the transporter is provided. Further, according to the present invention, a screening method which provides candidate substances for preventive agents and treatment agents for diseases related to polyamine metabolism is provided. According to the present invention, a kit for screening an activity modulating agent for polyamine transport proteins is also provided.
従来技術、競合技術の概要(英語) BACKGROUND ART
2 The polyamine is a primary amino group having one or more aliphatic, spermidine, spermine, putrescine and the like are present in a range of biology. A wide variety of physiological function and a polyamine (cell growth, cell differentiation promoting, protein synthesis-promoting effect, DNA stabilization, anti-oxidation activity, and, NMDA-type glutamate receptors and potassium channels in the act by modulating) is reported as antibacterial. Polyamines such as nerve cells and astrocytes accumulated in the vesicles, released to the outside the cell by stimulation, chemical transfer control and glutamic acid, as a result, the neurotransmission is controlling. Or less, a typical example thereof is described. (1) High lung damage under the high oxygen under oxygen hypoxic lung is damaged but, polyamine synthesis under hypoxic condition and an important survival of known (non-patent document 1 and 5). (2) Associated with a neurological disorder such as schizophrenia and schizophrenia, extrapyramidal syndrome (muscle tension-abnormal involuntary movement, finger tremor, muscle rigidity, jugular, the face portion Brick condensation, eyeball rotation stroke, impatience feeling and the like), mood disorders, anxiety, and a polyamine is associated with suicidal behavior (non-patent document 2). A neurological disorder of these NMDA receptor as a cause of hyperexcitability is said to be associated with. One of the polyamine agmatine is an anti-depression, anti-anxiety action, having mood disorders (non-patent document 2, 6, 7). (3) Is in the context of anti-NMDA receptor for eliprodil polyamine binding site, for the anti- (non-patent document 2, 6). (4) Neurodegenerative Alzheimer's disease, Parkinson's disease, ischemia, neurodegeneration associated with stroke in diseases such as, NMDA receptors play an important role in the hyperexcitability. It is possible to memantine NMDA receptors inhibit nerve hyperexcitability, neuronal cell death. Used as a therapeutic agent of Alzheimer's disease. Also, polyamine analog NMDA receptors reported to protect from the degeneration of the nerve through the (non-patent document 4) are.
Synaptic vesicle isolated polyamine transport is observed (non-patent document 8), a mechanism in which the polyamine which, via any transporter, the accumulation of vesicles or was unknown.
In the case of a prior art document information related to the invention, is the following.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY
  • 発明者(英語)
  • MORIYAMA, Yoshinori
  • OMOTE, Hiroshi
  • MIYAJI, Takaaki
  • HIASA, Miki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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