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METHOD FOR MANUFACTURING USEFUL SUBSTANCE IN WHICH HIGH-DENSITY CULTURED STRAIN OF FILAMENTOUS FUNGI IS USED

外国特許コード F150008174
掲載日 2015年3月19日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2013JP080352
国際公開番号 WO 2014073674
国際出願日 平成25年11月8日(2013.11.8)
国際公開日 平成26年5月15日(2014.5.15)
優先権データ
  • 特願2012-247276 (2012.11.9) JP
発明の名称 (英語) METHOD FOR MANUFACTURING USEFUL SUBSTANCE IN WHICH HIGH-DENSITY CULTURED STRAIN OF FILAMENTOUS FUNGI IS USED
発明の概要(英語) A problem to be resolved by the present invention is to allow filamentous fungi to be cultured in high density, and a useful substance to be thereby mass-produced. The present invention provides a method for manufacturing a substance, the method including: a step for culturing mutant-type filamentous fungi that do not express α-1,3-glucan, and causing the filamentous fungi to produce the substance; and a step for collecting the substance that was obtained.
従来技術、競合技術の概要(英語) BACKGROUND ART
And filamentous fungi, mycelia composed of those tubular referred to as a general term although, organic acid, dye, a chemical pesticide such as chromogen, penicillin, statins in the low-molecular compound such as pharmaceuticals and the like; amylase, cellulase, protease, lipase industrial fermentation production such as an enzyme used.
For example, in patent document 1, glucose-containing solution derived from thermophilic bacteria β - glucosidase was added and, by a condensation reaction step of preparing a solution containing 2 sugars, and sugars containing solution 2 using filamentous fungi culture medium containing the substrate to produce the cellulase, the cellulase is a method to prepare.
In addition, Patent Document 2 is, in the processing of the fungal peptide C- peptides and/or from the end of the peptide from the excision N- terminus, the amino acid sequence have a specific phospholipase activity to produce a core peptide comprising the steps of a method for producing the phospholipase.
In addition, the patent document 3-7, the production of the substance by the filamentous fungi to the purpose of improving the efficiency, the host filamentous fungi to function as a constructed expression vector, the expression vector also encodes a protein homologous or heterologous gene is functionally linked plasmid is introduced into the filamentous fungi transformants are prepared, the use of further transformant amylase, or cellulase enzymes such as, and low molecular weight compounds such as penicillin can contribute to increasing the production, is described.
As described above, filamentous fungi have, a wide variety has the advantage that produce a useful substance. However, filamentous fungi have, the liquid in the culture step, entangled hyphae aggregated into lumps, such a problem that the high density culture, leading to a decrease in the amount of production of useful materials, production of useful materials and a problem that a complex manufacturing step, has been attempted solved from various viewpoints (for example, Patent Document 8-9).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOHOKU UNIVERSITY
  • 発明者(英語)
  • ABE, Keietsu
  • GOMI, Katsuya
  • YOSHIMI, Kei
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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