Top > Search of International Patents > ANTICANCER DRUG COMPRISING CYCLIC RGD SEQUENCE-CONTAINING PEPTIDE

ANTICANCER DRUG COMPRISING CYCLIC RGD SEQUENCE-CONTAINING PEPTIDE

Foreign code F150008177
Posted date Mar 19, 2015
Country WIPO
International application number 2013JP082272
International publication number WO 2014084378
Date of international filing Nov 29, 2013
Date of international publication Jun 5, 2014
Priority data
  • P2012-261225 (Nov 29, 2012) JP
Title ANTICANCER DRUG COMPRISING CYCLIC RGD SEQUENCE-CONTAINING PEPTIDE
Abstract Provided is an anticancer drug which has advantages such as reduced gastrointestinal toxicity and less weight loss in patients. This anticancer drug comprises an anti-cancer active ingredient and a cyclic arginine-glycine-aspartic acid (RGD) sequence-containing peptide.
Outline of related art and contending technology BACKGROUND ART
Anti-cancer chemotherapy is a major option in cancer treatment, many anti-cancer active ingredient is, nontoxic to normal cells as well as tumor cells affect, the risk of side effects. In particular, conventional low molecule anti-cancer active ingredient, as well as a target tumor lesion, other normal tissue, and the organs on the drugs also widely distributed, metabolism and blood for a relatively short residence time, to maintain an effective concentration at the target site difficult. Accordingly, quantities of drug must be administered repeatedly tend, with which the possibility of an occurrence of side effects such as weight loss higher than the.
For this reason, from the viewpoint of reducing side effects, locally to the site to target anticancer drug delivery system for efficient delivery (Drug Delivery System: DDS) is, has been proposed.
For example, by a part of the inventors of the present invention (Japanese Patent Application Laid-Open 8-188541) patent document 1 is, uncharged segment and a charged segment of the block copolymer obtained by self-organization, capacitive coupling disclosed polymeric micelle type drug carrier.
In addition, the present inventors also part of the patent document 2 (International Publication No. 2005/056641 pamphlet) is, the above-described configuration of the capacitive coupling type polymeric micelle drug carrier, diaminocyclohexane platinum (II) activity of anti-tumor ingredient disclosed an anti-tumor agent.
In addition, a part of the inventors of the present invention also Patent Document 3 (pamphlet of International Publication No. 2006/118260) is, uncharged hydrophilic segments having a cationic segment and a block copolymer of 1 (for example PEG - polycation or the like) and, uncharged hydrophilic segment 2 having a first segment and an anionic block copolymer (for example PEG - polyanion or the like) obtained by self-organization and, capacitive coupling-type polymer vesicles disclosed drug carrier.
On the other hand, the non-patent document 1(Nasongkla et al., Nano Letters, (2006), 6, 11, 2427-30), doxorubicin-containing polymeric micelle cRGD peptide may be coupled to the hydrophilic block, improved anti-cancer effects reported.
Scope of claims (In Japanese)請求の範囲 [請求項1]
 抗癌活性成分と、環状アルギニン-グリシン-アスパラギン酸(RGD)配列含有ペプチドとを含む抗癌剤。

[請求項2]
 環状RGD配列含有ペプチドが抗癌活性成分に結合された、請求項1に記載の抗癌剤。

[請求項3]
 抗癌活性成分を担持する担体を更に含み、環状RGD配列含有ペプチドが担体に結合された、請求項1に記載の抗癌剤。

[請求項4]
 担体が、非荷電性セグメントと荷電性セグメントとを有するブロック共重合体からなる静電結合型高分子ミセルであり、抗癌活性成分がミセル内に包有される、請求項3に記載の抗癌剤。

[請求項5]
 抗癌活性成分が白金錯体成分である、請求項1~4の何れか一項に記載の抗癌剤。

  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • THE UNIVERSITY OF TOKYO
  • Inventor
  • KATAOKA, Kazunori
  • NISHIYAMA, Nobuhiro
  • MIURA, Yutaka
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

PAGE TOP

close
close
close
close
close
close