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AUTOANTIBODY DETECTION METHOD, METHOD FOR TESTING POSSIBILITY OF AUTOIMMUNE DISEASE CONTRACTION, AUTOANTIBODY DETECTION REAGENT, AND AUTOIMMUNE DISEASE TEST REAGENT 新技術説明会

外国特許コード F150008189
掲載日 2015年3月23日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP050796
国際公開番号 WO 2015008498
国際出願日 平成26年1月17日(2014.1.17)
国際公開日 平成27年1月22日(2015.1.22)
優先権データ
  • 特願2013-148833 (2013.7.17) JP
発明の名称 (英語) AUTOANTIBODY DETECTION METHOD, METHOD FOR TESTING POSSIBILITY OF AUTOIMMUNE DISEASE CONTRACTION, AUTOANTIBODY DETECTION REAGENT, AND AUTOIMMUNE DISEASE TEST REAGENT 新技術説明会
発明の概要(英語) An autoantibody detection method for detecting, with exceptional accuracy, an autoantibody causing an autoimmune disease is provided. An autoantibody detection method according to the present invention is characterized by the inclusion of a contact step for causing an antigen reagent including a denatured protein presented by a major histocompatibility complex (MHC) class II molecule and a sample to come into contact with each other and a detection step for detecting a complex of an autoantibody in the sample and the denatured protein in the antigen reagent. Further, using this detection method to detect a complex of the autoantibody and the denatured protein in a biological sample isolated from a subject makes it possible to test for the possibility of the contraction of an autoimmune disease by the subject on the basis of the detection results.
従来技術、競合技術の概要(英語) BACKGROUND ART
Diagnosis of autoimmune diseases, in general, based on the patient's symptoms or the like in addition to the direct determination, an autoimmune disease based on the detection of autoantibodies specific for the indirect determination is used. The self-detection of the antibody, typically, the purified antigen was immobilized on a carrier protein, the solid phase ELISA confirming the binding of the protein and the like are employed. However, by a doctor, a diagnosis of autoimmune disease based on symptoms even in the case where, in patients of all of them, can be detected by the ELISA method are no autoantibodies. Therefore, only by the detection of autoantibodies by ELISA method in which a battery is false negative, the diagnosis of autoimmune disease, in combination with other determination method is required. Thus, excellent in reliability for the diagnosis of autoimmune diseases, autoantibodies can be detected with excellent accuracy the establishment of a method is demanded.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • OSAKA UNIVERSITY
  • 発明者(英語)
  • ARASE Hisashi
  • TANIMURA Kenji
  • JIN Hui
  • ARASE Noriko
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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