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PEPTIDE-PRESENTING PROTEIN AND PEPTIDE LIBRARY EMPLOYING SAME 新技術説明会

外国特許コード F150008218
掲載日 2015年3月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP061366
国際公開番号 WO 2014175305
国際出願日 平成26年4月23日(2014.4.23)
国際公開日 平成26年10月30日(2014.10.30)
優先権データ
  • 特願2013-090524 (2013.4.23) JP
発明の名称 (英語) PEPTIDE-PRESENTING PROTEIN AND PEPTIDE LIBRARY EMPLOYING SAME 新技術説明会
発明の概要(英語) The purpose of the present invention is to provide a method for screening peptides displaying high specificity to a target molecule. The problem is solved by a peptide-presenting protein presenting a peptide in a presentation region from 131-139 in an amino acid sequence represented by SEQ ID NO: 54, wherein the peptide-presenting protein presents an amino acid sequence of 4-15 peptides inserted into the amino acid sequence of 131-139, or 1-9 amino acid sequences substituted into the amino acid sequence of 131-139, the chain length of the amino acid sequence corresponding to the amino acid sequence of 131-139 being 15 or less.
従来技術、競合技術の概要(英語) BACKGROUND ART
The function of binding to a target molecule with high specificity to an immunogenic peptide useful for drug discovery, in order to obtain them, various types of peptide display techniques and high throughput screening of generating peptide technologies have been developed. For specific presentation of the method include peptide libraries, phage display, presented method E. coli, or yeast is used in the present method or the like. For example, in phage, screening the peptides, as a fusion with a bacteriophage coat protein polypeptide is expressed. Peptide display phage particles, and the target substance is brought into contact with the immobilized microtiter plate, by performing affinity selection, a peptide having affinity for the target substance can be concentrated by a phage having (non-patent document 1). In a phage display library, concentrated and the displayed peptide to the phage, the gene encoding the corresponding 1 1 for the pair, the peptides of interest can be identified easily. In addition, can be easily amplified gene (growth), as a screening method for peptides, are widely used.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • 発明者(英語)
  • KADONOSONO Tetsuya
  • KONDOH Shinae
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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