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METHOD FOR PROVIDING VASCULAR SYSTEM IN BIOLOGICAL TISSUE

Foreign code F150008287
Posted date Apr 3, 2015
Country WIPO
International application number 2014JP068808
International publication number WO 2015012158
Date of international filing Jul 15, 2014
Date of international publication Jan 29, 2015
Priority data
  • P2013-153056 (Jul 23, 2013) JP
Title METHOD FOR PROVIDING VASCULAR SYSTEM IN BIOLOGICAL TISSUE
Abstract A method for providing a vascular system in biological tissue in vitro, the method comprising cocultivation of the biological tissue with vascular cells and mesenchymal cells. Biological tissue in which a vascular system has been provided by said method. A method for producing a tissue or organ, the method comprising transplantation of the biological tissue in a non-human animal and inducing differentiation to a tissue or organ in which a vascular network has been constructed. A tissue or organ regeneration or function-restoring method comprising transplantation of the biological tissue in a human or non-human animal and inducing differentiation to a tissue or organ in which a vascular network has been constructed. A method for producing a non-human chimera animal, the method comprising transplantation of the biological tissue to a non-human animal and inducing differentiation to a tissue or organ in which a vascular network has been constructed. A method for evaluating drugs using at least one selected from a group consisting of the biological tissue, tissues and organs produced by said method, and non-human chimera animals produced by said method. A regenerative therapy composition comprising biological tissue in which a vascular system has been provided by said method.
Scope of claims (In Japanese)[請求項1]
in vitroにおいて、生物学的組織に血管系を付与する方法であって、生物学的組織を血管細胞及び間葉系細胞と共培養することを含む、前記方法。
[請求項2]
足場材料を用いることなく、生物学的組織を血管細胞及び間葉系細胞と共培養する請求項1記載の方法。
[請求項3]
生物学的組織を血管細胞及び間葉系細胞と共培養することで、生物学的組織に血管系が付与され、生物学的組織の機能が維持及び/又は向上する請求項1又は2に記載の方法。
[請求項4]
請求項1~3のいずれかに記載の方法により、血管系が付与された生物学的組織。
[請求項5]
請求項4記載の生物学的組織を非ヒト動物に移植し、血管網が構築された組織又は臓器に分化させることを含む、組織又は臓器の作製方法。
[請求項6]
請求項4記載の生物学的組織をヒト又は非ヒト動物に移植し、血管網が構築された組織又は臓器に分化させることを含む、組織又は臓器の再生又は機能回復方法。
[請求項7]
請求項4記載の生物学的組織を非ヒト動物に移植し、血管網が構築された組織又は臓器に分化させることを含む、非ヒトキメラ動物の作製方法。
[請求項8]
請求項4記載の生物学的組織、請求項5記載の方法で作製された組織及び臓器、並びに請求項7記載の方法で作製された非ヒトキメラ動物からなる群より選択される少なくとも1つを用いて、薬剤を評価する方法。
[請求項9]
請求項4記載の生物学的組織を含む、再生医療用組成物。
[請求項10]
組織又は臓器を作製するために用いられる請求項9記載の組成物。
[請求項11]
組織又は臓器の再生又は機能回復を行うために用いられる請求項9記載の組成物。
[請求項12]
生体に移植した後、生物学的組織が血管網を有する組織又は臓器に分化する請求項9~11のいずれかに記載の組成物。
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • YOKOHAMA CITY UNIVERSITY
  • Inventor
  • TAKEBE TAKANORI
  • TANIGUCHI HIDEKI
  • TAKAHASHI YOSHINOBU
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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