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METHOD FOR DIAGNOSING ADULT T CELL LEUKEMIA AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR ADULT T CELL LEUKEMIA

外国特許コード F150008408
整理番号 S2013-0908-C0
掲載日 2015年7月21日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP061548
国際公開番号 WO 2014175375
国際出願日 平成26年4月24日(2014.4.24)
国際公開日 平成26年10月30日(2014.10.30)
優先権データ
  • 特願2013-092155 (2013.4.25) JP
発明の名称 (英語) METHOD FOR DIAGNOSING ADULT T CELL LEUKEMIA AND METHOD FOR SCREENING THERAPEUTIC AGENT FOR ADULT T CELL LEUKEMIA
発明の概要(英語) Provided are: a novel method for diagnosing adult T cell leukemia, a diagnosis kit therefor; a method for screening a therapeutic agent therefor; and a therapeutic agent. The expression level of SCYL2 gene in cells is detected and the detection result is applied to the method for diagnosing adult T cell leukemia or the method for screening a therapeutic agent therefor. A phosphorylation-inhibiting and/or dephosphorylating agent, which has an effect of inhibiting phosphorylation at least at one of the phosphorylation sites of PTEN protein selected from the group consisting of T382, T383 and S380 and/or an effect of dephosphorylating the same via the regulation of the expression of SCYL2 gene, is prepared.
従来技術、競合技術の概要(英語) BACKGROUND ART
PTEN gene, located on chromosome 10q23.3, have been identified as a tumor suppressor (non-patent document 1 and 2). PTEN protein is widely expressed in the cell and the whole body, foss fatih inositol lipid inositol phosphates (phosphatidylinositol-3, 4, 5-trisphosphate - 3, 4, 5 - trifoliatus scan fate; PIP3) dephosphorylation of the enzyme that catalyzes a reaction known as. PIP3 Is, PI3 kinase (PI3K) are combined in the cell, the protein kinase/AKT (PKB) results in activation of B. PTEN is, responsible for the dephosphorylated reaction of this PIP3, - 4, 5 - bisphosphate fate (phosphatidylinositol 4,5-bisphosphate foss fatih inositol; PIP2) and converted into the operable.
In this way is PTEN, PI3K/AKT information transmission system (non-patent document 3) negatively controls. On the other hand, and of inhibiting the activity of PTEN, there were PIP3 cells, PI3K/AKT signal transduction is activated. Such PI3K/AKT is the constitutive activation of signal transduction, diabetes, autism, involved in some types of cancers has been suggested (patent document 4). In addition, by the modification of PTEN, and its activity is been found to vary (non-patent document 5 and 6). Is to maintain the activity of PTEN, various important for diagnosis and treatment of disease.
Further, the wafer holding the activity of PTEN, PTEN phosphorylated sites in proteins T382, T383, and S380 selected from the group consisting of at least one site inhibits the phosphorylation or dephosphorylation can be important to the present invention that are discovered by the inventors (Patent Document 1).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • UNIVERSITY OF MIYAZAKI
  • 発明者(英語)
  • MORISHITA,Kazuhiro
  • ICHIKAWA,Tomonaga
  • NAKAHATA,Shingo
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG

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