TOP > 外国特許検索 > METHOD FOR PRODUCING AMBREIN

METHOD FOR PRODUCING AMBREIN 新技術説明会

外国特許コード F150008425
整理番号 S2013-1240-C0
掲載日 2015年10月9日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP071333
国際公開番号 WO 2015033746
国際出願日 平成26年8月12日(2014.8.12)
国際公開日 平成27年3月12日(2015.3.12)
優先権データ
  • 特願2013-184143 (2013.9.5) JP
発明の名称 (英語) METHOD FOR PRODUCING AMBREIN 新技術説明会
発明の概要(英語) A method for producing ambrein, which comprises reacting a tetraprenyl-β-curcumene cyclase with 3-deoxyachilleol A to produce ambrein.
従来技術、競合技術の概要(英語) BACKGROUND ART
Is aroma (ambergris), from the world around Day 7 st century has been used in perfume and higher, are also used as Chinese medicine. Is aroma , food (tachometer, squid and the like) are naturally occurring monoester of gastrointestinal secretions by not digest was allowed to stone, but it seems that the excretion, detailed generation mechanism is unknown. And the main component of the aroma , floating sea aroma between the degraded and oxidized by oxygen in the daylight, the odor of a product to produce the compound having various considered.
Is a main component aroma, fragrance or agent used as is, to the naturally occurring cannot be obtained in large quantities. For this reason, a variety of organic synthesis method has been proposed. For example, JP-10-236996 discloses, a simple and inexpensive (+) - as a method of manufacturing efficiently, from , and novel sulfonic acid derivative, optically active γ - to this coupling is disclosed comprising the step. In addition, is Tetrahedron Asymmetry, (2006) Vol.17, pp.3037-3045, (±) (- 2, 2 5, 5, 8a - - 1H - ' - oxirane -1 - yl) was synthesized from methanol 2-((1R,2R,4aS,8aS) -2-(methoxymethoxy) - 2, 5, 5, -1-8a - yl) acetaldehyde, (±) 5 - was synthesized from methyl 6 - hydroxy - 2, 2 - ((4 - ((S) - 2, 2 - dimethyl -6 - methylenecylohexyl) butane -2 - yl) sulfonyl) phenyl - 1H - tetrazole and -1 -, and converged by the synthesis Julia coupling reaction, disclosed a method of achieving a .
On the other hand, the mutant enzyme of the enzyme squalene cyclization - (D377C, D377N, Y420H, Y420W or the like) by using, from squalene, a triterpene bicyclic A 3 - is known a method of achieving a (Biosci. Biotechnol. Biochem., (1999) Vol.63, pp.2189-2198, Biosci. Biotechnol. Biochem., (2001) Vol.65, pp.2233-2242, Biosci. Biotechnol. Biochem., (2002) Vol.66, pp.1660-1670). In addition, the enzyme - β - cyclization, ring of the 4 - β - from C35 and a reaction, the triterpene squalene from the ring 2 and of the reaction, one 2 involved in a reaction of a bifunctional enzyme have been reported (J. Am. Chem. Soc., (2011) Vol.133, pp.17540-17543).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NIIGATA UNIVERSITY
  • 発明者(英語)
  • SATO, Tsutomu
  • UEDA, Daijiro
  • HOSHINO, Tsutomu
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
ライセンスをご希望の方、特許の内容に興味を持たれた方は、下記「問合せ先」までお問い合わせください。

PAGE TOP

close
close
close
close
close
close