Method for detecting regulatory T cells using expression of folate receptor 4 as indicator, method for treating diseases using the detection method, pharmaceutical composition for immunostimulation, and method for treating diseases using the composition
| 外国特許コード | F150008441 |
|---|---|
| 整理番号 | 734 |
| 掲載日 | 2015年10月21日 |
| 出願国 | アメリカ合衆国 |
| 出願番号 | 24036105 |
| 公報番号 | 20060246063 |
| 公報番号 | 7488474 |
| 出願日 | 平成17年10月3日(2005.10.3) |
| 公報発行日 | 平成18年11月2日(2006.11.2) |
| 公報発行日 | 平成21年2月10日(2009.2.10) |
| 優先権データ |
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| 発明の名称 （英語） | Method for detecting regulatory T cells using expression of folate receptor 4 as indicator, method for treating diseases using the detection method, pharmaceutical composition for immunostimulation, and method for treating diseases using the composition |
| 発明の概要（英語） |
(US7488474) An object of the present invention is to provide a technique to distinguish between Treg cells and activated T cells in a live state. Another object of the present invention is to provide a pharmaceutical composition for immunostimulation that can reduce the number of Treg cells in vivo and effectively express the immune response of activated T cells. In the method of the present invention, Treg cells are detected from test cells containing (i) regulatory T cells and (ii) at least one type of cell selected from the group consisting of naive T cells and activated T cells, wherein expressions of folate receptor 4 on the surfaces of cells are measured and Treg cells are detected using the expressions as an indicator. The present invention uses anti-folate receptor 4 antibody or folate receptor 4-binding fragment as an active ingredient contained in a pharmaceutical composition for immunostimulation. |
| 特許請求の範囲（英語） |
[claim1] 1. A method for treating a malignant tumor or infectious disease comprising: (a) collecting cells comprising T cells from a patient suffering from a malignant tumor or infectious disease;(b) inducing the T cells in the cells collected in (a) by subjecting the cells collected to an antigenic stimulus in vitro;(c) depleting from the resulting cells of (b), cells having the highest folate receptor 4 expression, so as to obtain cells comprising T cells from which regulatory T cells have been removed; and(d) administering the resulting depleted cells obtained in (c) to the patient. [claim2] 2. The method of claim 1, wherein step (c) is carried out by the method comprising: (i) measuring expression of folate receptor 4 on the surface of the T cells;(ii) detecting regulatory T cells using the expression as an indicator; and(iii) depleting regulatory T cells having the highest folate receptor 4 expression. [claim3] 3. The method of claim 1, wherein the folate receptor 4 expression is measured using an anti-folate receptor 4 antibody or a folate receptor 4-binding fragment. |
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