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METHOD FOR DETERMINING PROGNOSIS OF CANCER

Foreign code F150008455
File No. 4130
Posted date Oct 21, 2015
Country WIPO
International application number 2014JP063527
International publication number WO 2014185550
Date of international filing May 15, 2014
Date of international publication Nov 20, 2014
Priority data
  • P2013-104027 (May 16, 2013) JP
Title METHOD FOR DETERMINING PROGNOSIS OF CANCER
Abstract The present invention relates to a method for determining prognosis of cancer in a subject, which comprises the step of detecting phosphorylation of a tyrosine residue at position 2681 of TRIO in a sample obtained from the subject.
Outline of related art and contending technology BACKGROUND ART
Cancer is the leading cause of death in most industrialized nations, and the direct cause of cancer death is often its metastasis to the vital organs. Colorectal cancer is the third most common cause of cancer mortality in Japan. Every year, -100 new patients of colorectal cancer are diagnosed per population of 100,000, and the mortality rate is 30-40 per 100,000 patients ; and it is still increasing.
Cancer treatment, such as chemotherapy and radiation has associated risks, and it is important to optimally select patients most likely to benefit. Although there are several studies on prognostic markers for colorectal cancer (Non-patent literatures 1-7) , they are not enough to identify patients with good prognoses for whom risky therapy would not be necessary. CITATION LIST
  • Applicant
  • ※All designated countries except for US in the data before July 2012
  • KYOTO UNIVERSITY
  • Inventor
  • TAKETO, Makoto
  • SONOSHITA, Masahiro
  • SAKAI, Yoshiharu
  • KAWADA, Kenji
  • ITATANI, Yoshiro
IPC(International Patent Classification)
Specified countries National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN TD TG
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