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CATIONIC PEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

外国特許コード F150008564
整理番号 S2015-0952-N0
掲載日 2015年11月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2014JP076991
国際公開番号 WO 2015053338
国際出願日 平成26年10月8日(2014.10.8)
国際公開日 平成27年4月16日(2015.4.16)
優先権データ
  • 201361888200 (2013.10.8) US
発明の名称 (英語) CATIONIC PEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
発明の概要(英語) A cationic peptide comprising an amino acid sequence represented by formula (1) and a cationic peptide comprising an amino acid sequence represented by formula (2). [X1] a - Cys - (Z / Val)b - [X2]c - (Z / Val)d - Cys - [X3] e ⋅ Formula(1) [X1] a - (Z / Val)b - [X2]c - (Z / Val)d - [X3] e ⋅ Formula(2) [In formulas (1) and (2), Z represents an amino acid residue selected from the group consisting of 2,3-diaminopropionic acid (Dap), 2,4-diaminobutyric acid (Dab), ornithine (Orn), and lysine (Lys), Z/Val on both sides of [X2]c each independently represent Z-Val or Val-Z, X1 of number a each independently represent any amino acid residue, X2 of number c each independently represent any amino acid residue, X3 of number e each independently represent any amino acid residue, a represents 0 or an integer of 1 or higher, c represents 0 or an integer of 1 or higher, b represents an integer of 1 or higher, and d represents an integer of 1 or higher.]
従来技術、競合技術の概要(英語) BACKGROUND ART
Nucleic acid binding molecule is a nucleic acid or a pharmaceutically acceptable in vivo in order to improve the stability of the molecule is useful, in vivo for expression of the activity of a nucleic acid drug is, for a nucleic acid drug molecule to a nucleic acid drug ON, OFF control is required.
One of the nucleic acid binding molecules, and cationic peptides, cationic peptides upon binding to dsRNA, induced β - structure which is known to bind. Β - nucleic acid duplex structure coupled to the synthesis of the peptide and properties, R. Iwata, M. Sudo, K. Nagafuji, T. Wada, J. Org. Chem., 2011, 76, 5895-5906, and, Y. Maeda, R. Iwata, T. Wada, Bioorg. Med. Chem., 2013, 21, 1717-1723, reporting.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO UNIVERSITY OF SCIENCE FOUNDATION
  • NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
  • 発明者(英語)
  • WADA, Takeshi
  • MAEDA, Yusuke
  • YOKOTA, Takanori
  • NISHINA, Kazutaka
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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