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PHOTODETECTION DEVICE, PHOTODETECTION METHOD AND PROGRAM UPDATE 新技術説明会

外国特許コード F150008579
整理番号 (S2014-0567-N0)
掲載日 2015年11月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP053615
国際公開番号 WO 2015125665
国際出願日 平成27年2月10日(2015.2.10)
国際公開日 平成27年8月27日(2015.8.27)
優先権データ
  • 特願2014-033129 (2014.2.24) JP
発明の名称 (英語) PHOTODETECTION DEVICE, PHOTODETECTION METHOD AND PROGRAM UPDATE 新技術説明会
発明の概要(英語) Provided are: a photodetection device capable of establishing a phase-sensitive detection mechanism using electric processing, and quickly detecting faint light at a high degree of sensitivity by using a simple configuration; a photodetection method; and a program. This photodetection device includes: a light source unit for generating first pulsed light; a filter unit for allowing second pulsed light constituting a part of a frequency spectrum exhibited by the first pulsed light to pass therethrough, and reflecting third pulsed light constituting another part of the frequency spectrum exhibited by the first pulsed light; a phase modulation unit for phase-modulating the second pulsed light using a plurality of phases; a multiplexing unit for creating fourth pulsed light by multiplexing the third pulsed light and the second pulsed light which was phase-modulated by the phase modulation unit; and a detection unit for spectrally dispersing and detecting scattered light produced by irradiation of a target object by the fourth pulsed light. Furthermore, the photodetection device extracts the frequency spectrum of scattered light which is scattered on the basis of the second pulsed light which was phase-modulated by the phase modulation unit, from the frequency spectrum of the scattered light detected by the detection unit, by synchronization with the phase modulation by the phase modulation unit using a prescribed computation processing.
従来技術、競合技術の概要(英語) BACKGROUND ART
The present invention, the optical detection apparatus, the invention relates to a light detecting method and a program, in particular, the Raman spectroscopy technique is used in the analysis of the material of the light detecting device, the light detecting method and a program. That is, one or more of the pulse laser light 2 directed to the sample, as a result of the Raman scattered light emitted from the specimen by observing, in the case where a sample of the substance in the device for analysis.
Raman spectroscopic techniques for the detection of the trace substance, the analyzer is more important as the basic technique, many techniques have been developed. On the other hand, with advances in medical technology in recent years, techniques for detection of a trace substance in medical diagnosis and the application to have been tried, also in the field of medical diagnostic techniques to further improves the detection sensitivity of a trace substance as has been required.
Raman spectroscopy techniques as described above, the coherent Raman scattering method is known (Coherent Anti-stokes Raman Scattering; CARS) (Patent Document 1) are. This is, two or more of the light pulse by irradiating a sample, which occurs during their emitted from the sample by the non-linear optical processes (CARS light) coherent Raman scattering light are observed.
For example, as shown in Fig. 10 (a) a molecule having an energy level observed by means of CARS will be considered. First, in the initial energy level L1, with the angular frequency ω 1 the first pulsed light 1 (excitation light) is excited by the incidence of the sample molecules, its energy levels increases to L3 as shown by the arrow A. Then, with the angular frequency ω 2 the first (Stokes light) of the pulse light 2 is incident to, the photon emission energy of the molecule level is indicated by an arrow B from the drops L2 L3 as shown. Further angular frequency ω 3 of the pulse light 3 having a first (probe light) is incident, the energy level of the molecule, as shown by arrow C, up to L4 from L2, CARS light is generated as shown by arrow D, from L4 down to L1.
In this way, the angular frequency ω 1, ω 2, with ω 3 by incidence of the types of pulse 3, resulting in a so-called the four-wave mixing processes, as a result of having the angular frequency ω 1 + ω 3 - ω 2 CARS light is generated. The CARS light, the frequency difference Δ ω=ω 1 - ω 2 to the incident pulse, the energy level of the molecule to be observed particularly when the difference between the strong resonance. That may be employed in the real world view of the light pulse, Δ ω corresponds to the vibration mode frequencies of the molecule when it is thought that the strong signal can be obtained, such a vibration mode of the molecule can be detected. In addition, this technique is using pulsed light of the first type 2 of the pulse light 3 generated by the optical processes by causing the second pulse light 1, having an angular frequency of 2 ω 1 - ω 2 CARS also be realized by detecting the light.
(B) Fig. 10 is, the pulsed light is irradiated to the sample and the spectrum of the SP, CARS generated by irradiation with the SC light spectrum is shown. The light pulse corresponding to a portion of the spectrum SP Raman scattering occurs, the short wavelength side by Δ λ is the wavelength λ to the location where the transition occurs in the CARS spectrum of the SC. Δ λ is the transition width of this wavelength, generally referred to as Raman, the wave number n instead of the wavelength (λ is the reciprocal of the wavelength, cm-1) may also be represented in the present invention. Incidentally, in the following description, when referring to the wavelength of the pulse light is, at the center wavelength of the spectrum of the pulses are shown.
In Fig. 11, using this principle, a Raman spectroscopy apparatus 80 according to the prior art. Raman spectroscopic apparatus 80 is, 2 types of laser pulse light source 1 and the second laser pulse light source 82, the second laser pulse light source 2 84, 88 of the pulse light from the light source are at the same location of the sample for irradiating the optical system 86, CARS light emitted from the sample 88 by a detecting apparatus 90 is configured to include (Patent Document 1, Non-Patent Document 1). Then, for example, the first 2 and second 1 laser pulse light source 82 is emitted from the laser pulse light source 84 can be changed by changing the wavelength of pulsed light, and a specific molecule contained in the sample 88 is emitted from the CARS light can be selectively detected respectively.
CARS light, the intrinsic properties of the molecules of the sample 88 by the vibration of the molecule since the detected signal, for example in the case of a small amount of in vivo identification of molecules, such as a labeling substance for staining the trace molecules is not required. Therefore, in particular the labeled substance is composed of a molecular weight that is lower than when observing the small molecule compounds, the labeled substance without being blocked by the influence of the observation is made possible. In this manner, CARS light observation of the Raman spectroscopy apparatus, in particular to other methods of in vivo examination has advantages.
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • NATIONAL UNIVERSITY CORPORATION TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY
  • 発明者(英語)
  • SUZUKI, Takayuki
  • MISAWA, Kazuhiko
  • OBARA, Yuki
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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