TOP > 外国特許検索 > ANTI-MYRISTOYLATED PROTEIN ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, MYRISTOYLATED PROTEIN DETECTION KIT, DRUG, GENE, AND VECTOR

ANTI-MYRISTOYLATED PROTEIN ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, MYRISTOYLATED PROTEIN DETECTION KIT, DRUG, GENE, AND VECTOR

外国特許コード F150008595
整理番号 (S2014-0380-N0)
掲載日 2015年11月26日
出願国 世界知的所有権機関(WIPO)
国際出願番号 2015JP057287
国際公開番号 WO 2015137441
国際出願日 平成27年3月12日(2015.3.12)
国際公開日 平成27年9月17日(2015.9.17)
優先権データ
  • 特願2014-052535 (2014.3.14) JP
発明の名称 (英語) ANTI-MYRISTOYLATED PROTEIN ANTIBODY OR ANTIGEN-BINDING FRAGMENT THEREOF, MYRISTOYLATED PROTEIN DETECTION KIT, DRUG, GENE, AND VECTOR
発明の概要(英語) Provided is an anti-myristoylated protein antibody or antigen-binding fragment thereof, characterized by having a light-chain variable domain consisting of CDR-L1 comprising the amino acid sequence shown by Sequence No. 1, CDR-L2 comprising the amino acid sequence shown by Sequence No. 2, and CDR-L3 comprising the amino acid sequence shown by Sequence No. 3, and/or a heavy-chain variable domain consisting of CDR-H1 comprising the amino acid sequence shown by Sequence No. 4, CDR-H2 comprising the amino acid sequence shown by Sequence No. 5, and CDR-H3 comprising the amino acid sequence shown by Sequence No. 6.
従来技術、競合技術の概要(英語) BACKGROUND ART
Of the catalytic subunit of cAMP-dependent protein kinase by determining the primary sequence of the myristic acid is bonded to the N-terminus is discovered (see non-patent document 1.), Myristoylated proteins up to now reported 100 or more, a few percent of the total protein being under the myristoylation estimated from the genomic sequence (see non-patent document 2.).
And myristoylation, protein N-terminus having a carbon number of 14 saturated fatty acids and myristic acid is added which is a kind of post-translational modification, all this modification is ubiquitous in eukaryotic organisms N- myristoyl transferase (NMT: N-myristoyltransferase, see non-patent document 3.) By translation performed at the same time. Is myristoylation, ribosome during translation in a state of connecting the peptide chain, the N-terminal methionine by methionine N exposed by the removal of α-amino group of glycine, at the amide bonds is myristic acid NMT is caused by the added (see non-patent document 4.). Myristoylation consensus sequence is not present, from the end of the 1 th N Glycine and necessarily, the first 2 amino acids have an electric charge (however, proline, except for the aromatic amine), the first 5 amino acids have an electric charge, is often present in particular serine, and the fourth amino acid except proline 6, the tendency of the filter (see non-patent document 5.).
Proteins involved in intracellular signal transmission system is found in many myristoylation, protein and the cell membrane of reversible due to the interaction with functions. For example, HIV Nef gene product or, myristoylation cancer Src kinase gene product is involved in the functional expression of the protein has been reported (non-patent document 6, the reference 7.). In addition, if the mutations in the N-terminal glycine that fails to become myristoylated protein in the cell membrane and could not be combined, as a result, even when there is no metastatic activity of cancer also are also suggested.
Membrane - protein, or protein - specific interactions between the proteins via, or cellular localization of the protein by performing the activity involved in intracellular signaling and detection of myristoylated proteins, the operation of each one of the cells is important for an understanding of the mechanism of that material (non-patent document 8, the reference 9.).
  • 出願人(英語)
  • ※2012年7月以前掲載分については米国以外のすべての指定国
  • TOKYO INSTITUTE OF TECHNOLOGY
  • 発明者(英語)
  • HAYASHI Nobuhiro
国際特許分類(IPC)
指定国 National States: AE AG AL AM AO AT AU AZ BA BB BG BH BN BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IR IS JP KE KG KN KP KR KZ LA LC LK LR LS LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PA PE PG PH PL PT QA RO RS RU RW SA SC SD SE SG SK SL SM ST SV SY TH TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LR LS MW MZ NA RW SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ RU TJ TM
EPO: AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW KM ML MR NE SN ST TD TG
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